Boros L, Bhaskar A G, D'Souza J P
Am J Clin Pathol. 1981 Jun;75(6):856-60. doi: 10.1093/ajcp/75.6.856.
A patient with angioimmunoblastic lymphadenopathy diagnosed on initial lymph node biopsy was found on rebiopsy two months later to have immunoblastic lymphoma as well. At presentation she had polyclonal hypergammaglobulinemia with polyclonal (kappa and lambda light chains) immunoblasts demonstrated by the immunoperoxidase stain. During the course of her illness, a monoclonal IgM kappa gammaglobulinemia developed, accompanied by monoclonal (kappa light chains only) immunoblasts demonstrated by the immunoperoxidase method. These findings were unique in that lymphomatous transformation and clinical deterioration are shown to be accompanied by a monoclonal evolution of immunoblasts. This constitutes further evidence for the heterogeneous nature of patients who have angioimmunoblastic lymphadenopathy and the malignant potential of this disease.
一名最初经淋巴结活检诊断为血管免疫母细胞性淋巴结病的患者，在两个月后的再次活检时也被发现患有免疫母细胞性淋巴瘤。初诊时她有多克隆高球蛋白血症，免疫过氧化物酶染色显示有多克隆（κ和λ轻链）免疫母细胞。在病程中，出现了单克隆IgM κ型球蛋白血症，免疫过氧化物酶法显示伴有单克隆（仅κ轻链）免疫母细胞。这些发现很独特，因为淋巴瘤转化和临床恶化显示与免疫母细胞的单克隆演变相关。这进一步证明了血管免疫母细胞性淋巴结病患者的异质性以及该疾病的恶性潜能。
