Department of Psychiatry, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
Brain Research Institute, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
J Diabetes Res. 2023 Nov 8;2023:7887792. doi: 10.1155/2023/7887792. eCollection 2023.
Type 2 diabetes (T2D) and neurodegenerative diseases (NDs) are common among elderly individuals. Growing evidence has indicated a strong link between T2D and NDs, such as Alzheimer's disease. However, previous studies have limitations in exploring the epidemiological relationship among these diseases as a group of NDs rather than as a specific type of ND. We aimed to investigate the risk of NDs in elderly Koreans who were first diagnosed with T2D and determine the association between T2D and NDs. We conducted a retrospective longitudinal cohort study of patients with who were initially diagnosed with T2D using the Korean National Health Information Database. The study participants were categorized into a T2D group ( = 155,459) and a control group ( = 155,459), aged 60-84 years, that were matched for age, sex, and comorbidities. We followed the participants for 10 years to investigate the incidence of NDs. The Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for NDs. The numbers of patients diagnosed with ND at the end of follow-up were as follows: 51,096/155,459 (32.9%) in the T2D group and 44,673/155,459 (28.7%) in the control group ( = 622.53, < 0.001). The incidences of NDs in the T2D and control groups were 44.68 (95% CI: 44.29, 45.07) and 36.89 (95% CI: 36.55, 37.24) cases per 1,000 person-years at risk, respectively. The overall incidence of NDs was higher in the T2D group than that in the control group (HR: 1.23, 95% CI: 1.22, 1.25, < 0.001). This study revealed a higher incidence of NDs in elderly Koreans who were initially diagnosed with T2D. This suggests that T2D is a risk factor for NDs in elderly Koreans.
2 型糖尿病（T2D）和神经退行性疾病（NDs）在老年人中很常见。越来越多的证据表明，T2D 与 NDs 之间存在很强的关联，如阿尔茨海默病。然而，以前的研究在探索这些疾病作为一组 NDs 而不是作为一种特定类型的 ND 的流行病学关系方面存在局限性。我们旨在研究首次被诊断为 T2D 的老年韩国人患 NDs 的风险，并确定 T2D 与 NDs 之间的关系。我们使用韩国国家健康信息数据库对首次被诊断为 T2D 的患者进行了回顾性纵向队列研究。研究参与者分为 T2D 组（=155459）和对照组（=155459），年龄在 60-84 岁之间，按年龄、性别和合并症进行匹配。我们对参与者进行了 10 年的随访，以调查 NDs 的发病率。Cox 比例风险回归模型用于估计 NDs 的风险比（HR）和 95%置信区间（CI）。随访结束时被诊断为 ND 的患者人数如下：T2D 组 51096/155459（32.9%），对照组 44673/155459（28.7%）（=622.53，<0.001）。T2D 组和对照组 NDs 的发病率分别为 44.68（95%CI：44.29，45.07）和 36.89（95%CI：36.55，37.24）/1000 人年。T2D 组的 NDs 总发病率高于对照组（HR：1.23，95%CI：1.22，1.25，<0.001）。这项研究表明，在首次被诊断为 T2D 的老年韩国人中，NDs 的发病率较高。这表明 T2D 是老年韩国人 NDs 的一个危险因素。
