Gheisari Rasul, Saatchi Masoud, Estakhri Firoozeh, Vossoughi Mehrdad, Bazaei Mohammad, Khosravani Zahra
Private Practice, Maxillofacial Surgeon, Shiraz, Iran.
Department of Endodontics, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2023 Oct 26;20:106. eCollection 2023.
Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in single-kidney rats.
The present experimental animal study with two control groups was done in an animal laboratory. Forty-two rats were randomly assigned to seven groups of six rats, including two control groups and five experimental groups. The experimental groups underwent intraperitoneal anesthesia with 2% lidocaine, 2% lidocaine with 1:80,000 epinephrine, 4% articaine, 3% prilocaine with 0.03 IU Felypressin, and 3% mepivacaine, respectively. Unilateral nephrectomy was done. After 24 h, the rats' blood urea nitrogen (BUN), serum creatinine (Cr), and blood specific gravity (BSG) were measured. A standard dose of anesthetics was injected into the peritoneum for 4 days afterward. Then, these indices were measured again 24 h after the last injection. Data were analyzed using IBM SPSS (version 21.0). One-way analysis of variance, Tukey's honestly significant difference , and paired -tests were used for statistical analysis. < 0.05 was considered statistically significant.
The results indicated significant differences among groups in the rats' BUN and serum Cr 24 h after nephrectomy ( < 0.05). However, there were no significant differences in BUN, BSG, and Cr among groups after the interventions.
LAs did not affect renal function in single-kidney rats. Therefore, dentists can use the anesthetics in single-kidney people.
尽管局部麻醉药（LAs）的大部分代谢发生在肝脏，但尚无研究调查这些麻醉药对单肾人类或动物肾功能的影响。本研究旨在探讨局部麻醉药对单肾大鼠肾功能的影响。
本实验动物研究设有两个对照组，在动物实验室进行。42只大鼠被随机分为7组，每组6只，包括两个对照组和五个实验组。实验组分别接受2%利多卡因、含1:80,000肾上腺素的2%利多卡因、4%阿替卡因、含0.03 IU去甲肾上腺素的3%丙胺卡因和3%甲哌卡因的腹腔麻醉。进行单侧肾切除术。24小时后，测量大鼠的血尿素氮（BUN）、血清肌酐（Cr）和血液比重（BSG）。之后连续4天向腹腔注射标准剂量的麻醉药。然后，在最后一次注射后24小时再次测量这些指标。数据使用IBM SPSS（版本21.0）进行分析。采用单因素方差分析、Tukey's 真实显著性差异检验和配对检验进行统计分析。P < 0.05被认为具有统计学意义。
结果表明，肾切除术后24小时，各组大鼠的BUN和血清Cr存在显著差异（P < 0.05）。然而，干预后各组之间的BUN、BSG和Cr无显著差异。
局部麻醉药不影响单肾大鼠的肾功能。因此，牙医可以在单肾人群中使用这些麻醉药。
