Chelepy William, Yousif Saif, Nichols Paul Robert
Department of Neurosurgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Int Med Case Rep J. 2023 Nov 20;16:767-773. doi: 10.2147/IMCRJ.S428579. eCollection 2023.
Intraosseous schwannoma is a rare diagnosis, particularly so in the skull. Accordingly, little data exists to unify common features of this disease. Here, we present the fourth known case of a primary intraosseous schwannoma of the frontal bone: a 46-year-old male with severe, progressive headache and an osteolytic frontal bone lesion. Gross total resection of the lesion was performed with excellent clinical outcome. Histological analysis confirmed the diagnosis. The limited existing literature on this topic was reviewed to identify emerging trends surrounding presenting symptoms and treatment. Early literature suggests symptoms are often nonspecific, except for lesions of the petrous apex. No cases of recurrence have been demonstrated after gross total resection, though incomplete resection has been associated with recurrence. This diagnosis appears to be becoming a more often-considered differential for osteolytic, expansile skull lesions.
骨内神经鞘瘤是一种罕见的诊断，在颅骨中尤为如此。因此，几乎没有数据来统一这种疾病的常见特征。在此，我们报告第四例已知的额骨原发性骨内神经鞘瘤病例：一名46岁男性，患有严重的进行性头痛和额骨溶骨性病变。对病变进行了全切除，临床效果良好。组织学分析证实了诊断。回顾了关于该主题的有限现有文献，以确定围绕症状表现和治疗的新趋势。早期文献表明，症状通常是非特异性的，岩尖病变除外。全切除术后尚未有复发病例报道，不过不完全切除与复发有关。这种诊断似乎越来越常被视为溶骨性、膨胀性颅骨病变的鉴别诊断。
