Rais Fadoua, Benhmidou Naoual, Rais Ghizlane, Kouhen Fadila, Bellahamou Khadija, Loughlimi Hasna, Maghous Abdelhak, Elmejjaoui Sanae, Elkacemi Hanan, Kebdani Tayeb, Benjaafar Noureddine
Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco.
Department of Oncology, National Institute of Oncology, Rabat, Morocco.
Clin Sarcoma Res. 2015 Feb 9;5:6. doi: 10.1186/s13569-015-0023-1. eCollection 2015.
Intra-osseous schwannoma is a rare mesenchymal tumor. Although, the head and neck region is one of the most common sites for schwannomas, its location at the skull bone is uncommon and accounted for less than 0.2% in the largest series of bone tumors ever reported. Furthermore, it is most often a benign tumor, malignant transformation is exceedingly rare. Clinical presentation is non-specific, most often symptoms are associated with compression and invasion of adjacent organs. Neuro-imaging features are non-specific and the diagnosis is based on histological examination with immunohistochemical study. Surgery remains the aim of treatment. However, radiation therapy could be an interesting therapeutic option in unresectable tumors. This systemic review offers new clinicopathological data useful for better defining the diagnosis and clinicopathological behavior of schwannoma. The purpose of this work is to raise awareness among clinicians adding this clinical entity as a differential diagnosis when a mass of skull bone is identified.
骨内神经鞘瘤是一种罕见的间叶组织肿瘤。虽然头颈部是神经鞘瘤最常见的部位之一，但其位于颅骨的情况并不常见，在以往报道的最大系列骨肿瘤中占比不到0.2%。此外，它大多是良性肿瘤，恶性转化极为罕见。临床表现无特异性，最常见的症状与邻近器官的受压和侵犯有关。神经影像学特征无特异性，诊断基于组织学检查及免疫组化研究。手术仍是治疗的目标。然而，放射治疗对于无法切除的肿瘤可能是一种有意义的治疗选择。本系统评价提供了新的临床病理数据，有助于更好地明确神经鞘瘤的诊断及临床病理行为。这项工作的目的是提高临床医生的认识，当发现颅骨肿物时将这一临床实体作为鉴别诊断之一。
