1-萘酚对L1210白血病细胞的体内抗肿瘤活性以及对艾氏腹水瘤细胞的体内外抗肿瘤活性。
Antitumour activity of 1-naphthol against L1210 leukaemia in vivo and Ehrlich ascites tumour cells in vivo and in vitro.
作者信息
Jones M, d'Arcy Doherty M, Cohen G M
出版信息
Cancer Lett. 1986 Dec;33(3):347-54. doi: 10.1016/0304-3835(86)90075-3.
PMID:3802063
Abstract
1-Naphthol inhibited ascitic fluid formation in mice infected intraperitoneally with either L1210 leukaemia or Ehrlich ascites tumour cells (EATC). A significant increase in life span was observed in EATC but not in L1210 bearing mice dosed with 1-naphthol (50-60 mg/kg). 1-Naphthol caused a concentration-dependent toxicity to EATC in vitro.
摘要
1-萘酚可抑制经腹腔感染L1210白血病细胞或艾氏腹水瘤细胞（EATC）的小鼠的腹水形成。在用1-萘酚（50 - 60毫克/千克）给药的携带EATC的小鼠中观察到寿命显著延长，但携带L1210细胞的小鼠未出现这种情况。1-萘酚在体外对EATC具有浓度依赖性毒性。
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