聚乙二醇400对小鼠阿霉素毒性的影响。

Effect of polyethylene glycol 400 on adriamycin toxicity in mice.

作者信息

Klugmann F B, Decorti G, Mallardi F, Klugmann S, Baldini L

出版信息

Eur J Cancer Clin Oncol. 1984 Mar;20(3):405-10. doi: 10.1016/0277-5379(84)90088-9.

Abstract

The effect of a widely used organic solvent, polyethylene glycol 400 (PEG 400), on the toxic action of an acute or chronic treatment with adriamycin (ADR) was evaluated in mice. PEG 400 impressively decreased both acute high-dose and chronic low-dose-ADR-associated lethality. Light microscopic analysis showed a significant protection against ADR-induced cardiac morphological alterations. Such treatment did not diminish the ADR antitumor activity in L1210 leukemia and in Ehrlich ascites tumor.

摘要

在小鼠中评估了一种广泛使用的有机溶剂聚乙二醇400（PEG 400）对阿霉素（ADR）急性或慢性治疗毒性作用的影响。PEG 400显著降低了急性高剂量和慢性低剂量ADR相关的致死率。光学显微镜分析显示对ADR诱导的心脏形态改变有显著保护作用。这种治疗并未降低ADR对L1210白血病和艾氏腹水瘤的抗肿瘤活性。