Sun Mengyang, Liu Hao, Zhu Bingqing, Liu Yang, Li Aijia, Wang Limei
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhengzhou University Medical College, Zhengzhou, China.
Front Neurol. 2023 Oct 26;14:1266067. doi: 10.3389/fneur.2023.1266067. eCollection 2023.
Glial fibrillary acidic protein-immunoglobulin G (GFAP-IgG)-associated myelitis and myelin oligodendrocyte glycoprotein-IgG (MOG-IgG)-associated myelitis have rarely been compared. Therefore, this study aimed to explore the clinical, laboratory, and imaging features of them to identify the differences.
Overall, 14 and 24 patients with GFAP-IgG-and MOG-IgG-associated myelitis, respectively, were retrospectively screened and included in the study.
Among the 14 patients with GFAP-IgG-associated myelitis, the condition was more common in males (71.4%), with a median age of onset of 36.5 years, and more common in adults than in children (35.7%). In contrast, among the 24 patients with MOG-IgG-associated myelitis, the condition was equally divided between males and females, with a median age of onset of 9.5 years and more in children (66.7%) than in adults. The median age of onset of GFAP-IgG-associated myelitis was later than that of the MOG-IgG group. Isolated myelitis was rare in both groups. Elevated cerebrospinal fluid (CSF) protein levels were more prevalent in patients with GFAP-IgG-associated myelitis (64.3%) than in those with MOG-IgG-associated myelitis (16.7%) ( < 0.05), whereas patchy gadolinium enhancement of the cerebral lesion site was less common in patients with GFAP-IgG-associated myelitis than in those with MOG-IgG associated myelitis ( < 0.05). Six patients had a combination of other neurological autoantibodies, the specific mechanism of the overlapping antibodies remains unclear.
Cerebrospinal fluid analysis and gadolinium enhanced MRI examination may help to distinguish the two kinds of myelitis.
很少有研究对胶质纤维酸性蛋白 - 免疫球蛋白G（GFAP - IgG）相关脊髓炎和髓鞘少突胶质细胞糖蛋白 - 免疫球蛋白G（MOG - IgG）相关脊髓炎进行比较。因此，本研究旨在探讨它们的临床、实验室和影像学特征以找出差异。
本研究回顾性筛选了分别患有GFAP - IgG相关脊髓炎和MOG - IgG相关脊髓炎的14例和24例患者并纳入研究。
在14例GFAP - IgG相关脊髓炎患者中，该疾病在男性中更为常见（71.4%），中位发病年龄为36.5岁，且在成人中比儿童中更常见（35.7%）。相比之下，在24例MOG - IgG相关脊髓炎患者中，男女比例均等，中位发病年龄为9.5岁，儿童患者更多（66.7%），成人患者较少。GFAP - IgG相关脊髓炎的中位发病年龄晚于MOG - IgG组。两组中孤立性脊髓炎均少见。脑脊液（CSF）蛋白水平升高在GFAP - IgG相关脊髓炎患者中（64.3%）比在MOG - IgG相关脊髓炎患者中（16.7%）更普遍（P<0.05），而GFAP - IgG相关脊髓炎患者脑病变部位斑片状钆增强比MOG - IgG相关脊髓炎患者少见（P<0.05）。6例患者合并有其他神经自身抗体，重叠抗体的具体机制尚不清楚。
脑脊液分析和钆增强磁共振成像检查可能有助于区分这两种脊髓炎。
