髓鞘少突胶质细胞糖蛋白-IgG相关疾病中脑脊液检查结果随发作表型的变异性
Variability of cerebrospinal fluid findings by attack phenotype in myelin oligodendrocyte glycoprotein-IgG-associated disorder.
作者信息
Sechi Elia, Buciuc Marina, Flanagan Eoin P, Pittock Sean J, Banks Samantha A, Lopez-Chiriboga A Sebastian, Bhatti M Tariq, Chen John J
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
出版信息
Mult Scler Relat Disord. 2021 Jan;47:102638. doi: 10.1016/j.msard.2020.102638. Epub 2020 Nov 23.
BACKGROUND
The variability in cerebrospinal fluid (CSF) findings of myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is not fully elucidated.
OBJECTIVE AND METHODS
We retrospectively analyzed 203 attack-associated CSFs from Mayo Clinic patients (2000-2019) with MOGAD.
RESULTS
White-blood-cell (>5/mm) elevation was less with clinically isolated optic neuritis (23%), compared to myelitis, brain/brainstem attacks, or combinations thereof (>70%), p<0.0001. CSF pleocytosis in optic neuritis was more common in patients with coexisting asymptomatic brain and/or spine MRI T2-lesions (53%) than in those without (16%), p=0.005. Abnormal CSF oligoclonal bands ranged from 1% (optic neuritis) to 18% (brain/brainstem attacks). CSF pleocytosis was less common after immunotherapy.
CONCLUSIONS
CSF findings in MOGAD vary by attack phenotype and preceding treatment.
背景
髓鞘少突胶质细胞糖蛋白-IgG相关疾病（MOGAD）脑脊液（CSF）检查结果的变异性尚未完全阐明。
目的和方法
我们回顾性分析了梅奥诊所2000年至2019年期间203例MOGAD发作相关的脑脊液样本。
结果
与脊髓炎、脑/脑干发作或两者合并发作（>70%）相比，临床孤立性视神经炎患者脑脊液白细胞计数升高（>5/mm）的比例较低（23%），p<0.0001。共存无症状脑和/或脊柱MRI T2病变的视神经炎患者脑脊液细胞增多症更为常见（53%），而无此类病变的患者中脑脊液细胞增多症的比例为16%，p=0.005。脑脊液寡克隆带异常的比例从视神经炎患者的1%到脑/脑干发作患者的18%不等。免疫治疗后脑脊液细胞增多症较少见。
结论
MOGAD的脑脊液检查结果因发作表型和先前治疗而异。
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