Kumar Vivig Shantha
Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Brain Circ. 2023 Sep 27;9(3):135-147. doi: 10.4103/bc.bc_95_22. eCollection 2023 Jul-Sep.
Bacterial meningitis is a serious, life-threatening infection of the meninges. Several radiological studies highlight prominent structural alterations occurring in the cerebral vasculature, leading to significant cerebrovascular consequences during bacterial meningitis. Beginning with reflexive arterial vasospasm , cerebrovascular disease during bacterial meningitis proceeds through a orderly sequence of arterial vasculitis with inflammatory cell infiltration, medial smooth muscle migration and proliferation, medial necrosis, adventitial fibrosis and eventual intimal stenosis. As such, this review focuses on changes occurring within cerebral arteries during disease progression, highlighting the various structural modifications occurring in the arterial vessels that contribute to disturbances in cerebral hemodynamics and, ultimately, cerebrovascular consequences during bacterial meningitis.
细菌性脑膜炎是一种严重的、危及生命的脑膜感染。多项放射学研究强调了在细菌性脑膜炎期间，脑循环系统中发生的显著结构改变，这些改变会导致严重的脑血管后果。细菌性脑膜炎期间的脑血管疾病始于反射性动脉血管痉挛，随后依次经历动脉血管炎伴炎性细胞浸润、中膜平滑肌迁移和增殖、中膜坏死、外膜纤维化以及最终的内膜狭窄。因此，本综述聚焦于疾病进展过程中脑动脉内发生的变化，突出动脉血管中发生的各种结构改变，这些改变会导致脑血流动力学紊乱，并最终引发细菌性脑膜炎期间的脑血管后果。
