一种代谢物在苏丹红I致敏性中的作用。

Rôle of a metabolite in allergenicity of Sudan I.

作者信息

Kato S, Itagaki H, Uchiyama M, Kobayashi T, Fujiyama Y

出版信息

Contact Dermatitis. 1986 Oct;15(4):205-10. doi: 10.1111/j.1600-0536.1986.tb01337.x.

DOI:10.1111/j.1600-0536.1986.tb01337.x

Abstract

A metabolite of Sudan I (1-phenylazo-2-naphthol) was isolated after in vitro incubation with the supernatant of guinea pig liver homogenate (S-9). The metabolite was found to be 4'-hydroxy-1-phenylazo-2-naphthol by gas chromatography-mass spectrometry (GC-MS), and proton and carbon-13 nuclear magnetic resonance (NMR) analyses. It elicited positive reactions in guinea pigs sensitized to Sudan I. It was also shown to be allergenic. The results suggest that para-hydroxylation of the phenyl group of Sudan I may play an important rôle in its allergenicity.

摘要

苏丹红I（1-苯基偶氮-2-萘酚）与豚鼠肝脏匀浆上清液（S-9）进行体外孵育后，分离出一种代谢产物。通过气相色谱-质谱联用仪（GC-MS）以及质子和碳-13核磁共振（NMR）分析，发现该代谢产物为4'-羟基-1-苯基偶氮-2-萘酚。它在对苏丹红I致敏的豚鼠中引发了阳性反应。研究还表明它具有致敏性。结果表明，苏丹红I苯环的对羟基化可能在其致敏性中起重要作用。