飞秒激光原位角膜磨镶术后角膜生物力学及角膜后表面高度的变化
Changes in corneal biomechanics and posterior corneal surface elevation after FS-LASIK.
作者信息
Li Zhong-Ji, Yang Chen, Liu Su-Han, Guo Jiao, Duan Yu-Hui
机构信息
Department of Ophthalmology, Xi'an Gaoxin Hospital, Xi'an 710075, Shaanxi Province, China.
出版信息
Int J Ophthalmol. 2023 Nov 18;16(11):1832-1837. doi: 10.18240/ijo.2023.11.15. eCollection 2023.
AIM
To investigate the changes in corneal biomechanics and posterior corneal surface elevation after femtosecond laser-assisted keratomileusis (FS-LASIK).
METHODS
Totally 197 eyes of 100 patients who underwent the FS-LASIK from April 2022 to November 2022 were included. They were divided into three groups according to the ratio of residual corneal stroma thickness/corneal thickness (RCST/CT): Group I (50%≤RCST/CT<55%, 63 eyes of 32 patients), Group II (55%≤RCST/CT<60%, 67 eyes of 34 patients), and Group III (RCST/CT≥60%, 67 eyes of 34 patients). The intraocular pressure (IOP), corneal compensated IOP (IOPcc), corneal hysteresis (CH) and corneal resistance factor (CRF) were measured immediately, 1, and 3mo postoperatively by ocular response analyzer (ORA) and the posterior elevation difference (PED) was measured by Pentacam.
RESULTS
After operation, IOP, CH, CRF, and PED were statistically different among the three groups (=12.99, 31.148, 23.998, all <0.0001). There was no statistically significant difference in IOPcc among the three groups (=0.603, >0.05). The IOP, IOPcc, CH, and CRF were statistical changed after surgery (=699.635, 104.125, 308.474, 640.145, all <0.0001). The PED of Group I was significantly higher than that of Group II (<0.05), and Group II was significantly higher than that of Group III (<0.05). The PED value of 3mo after surgery decreased in each group compared with 1mo after surgery, but there was no statistical difference (Group I: =0.82, =0.41; Group II: =0.17, =0.87; Group III: =1.35, =0.18). The correlation analysis of corneal biomechanical parameter changes with PED at 1mo and 3mo after surgery showed that ΔIOP, ΔIOPcc, ΔCH, and ΔCRF were not correlated with PED value in three groups (>0.05).
CONCLUSION
The smaller the RCST/CT, the greater effect on corneal biomechanics and posterior surface elevation. There is no correlation between changes in corneal biomechanics and posterior corneal surface elevation in the range of RCST/CT≥50%.
目的
探讨飞秒激光制瓣准分子原位角膜磨镶术（FS-LASIK）后角膜生物力学及角膜后表面高度的变化。
方法
纳入2022年4月至2022年11月行FS-LASIK手术的100例患者的197只眼。根据剩余角膜基质厚度/角膜厚度（RCST/CT）的比例将其分为三组：I组（50%≤RCST/CT<55%，32例患者的63只眼），II组（55%≤RCST/CT<60%，34例患者的67只眼），III组（RCST/CT≥60%，34例患者的67只眼）。术后即刻、1个月和3个月时，使用眼反应分析仪（ORA）测量眼压（IOP）、角膜补偿眼压（IOPcc）、角膜滞后（CH）和角膜阻力因子（CRF），使用Pentacam测量后表面高度差（PED）。
结果
术后，三组间IOP、CH、CRF和PED差异有统计学意义（=12.99，31.148，23.998，均<0.0001）。三组间IOPcc差异无统计学意义（=0.603，>0.05）。术后IOP、IOPcc、CH和CRF有统计学变化（=699.635，104.125，308.474，640.145，均<0.0001）。I组的PED显著高于II组（<0.05），II组显著高于III组（<0.05）。与术后1个月相比，术后3个月时每组的PED值均降低，但差异无统计学意义（I组：=0.82，=0.41；II组：=0.17，=0.87；III组：=1.35，=0.18）。术后1个月和3个月时角膜生物力学参数变化与PED的相关性分析显示，三组中ΔIOP、ΔIOPcc、ΔCH和ΔCRF与PED值均无相关性（>0.05）。
结论
RCST/CT越小，对角膜生物力学和后表面高度的影响越大。在RCST/CT≥50%范围内，角膜生物力学变化与角膜后表面高度变化无相关性。
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