Zolotareva A G, Nikolin V P, Subkhankulova T N, Kaledin V I, Gruntenko E V
Eksp Onkol. 1986;8(6):28-32.
The fragments of cell plasma membranes of two lines of metastatic tumour of A/He mice (lung adenocarcinoma--LA-cells and hepatoma HA-1--HA-cells) were used to prepare "hybrid" vesicles (LA- and HA-liposomes). Incorporation of the fragments of LA-cells into the bilayer vesicle increased the binding of LA-liposomes with lung almost by an order of magnitude, their trapping by liver being noticeably decreased. HA-liposomes were retained in the liver in larger amounts than the model phospholipid liposomes. It is assumed that the specificity of metastatic spreading into an organ is associated with the interaction of the plasma membrane of the tumour cells with the apical membrane of the target organ endothelium.
利用A/He小鼠的两株转移性肿瘤（肺腺癌-LA细胞和肝癌HA-1-HA细胞）的细胞质膜片段制备“杂交”囊泡（LA-和HA-脂质体）。将LA细胞片段掺入双层囊泡中，使LA-脂质体与肺的结合增加了近一个数量级，而肝脏对它们的捕获明显减少。HA-脂质体在肝脏中的保留量比模型磷脂脂质体更多。据推测，肿瘤细胞向器官转移扩散的特异性与肿瘤细胞质膜与靶器官内皮顶端膜的相互作用有关。
