Zolotareva A G, Nikolin V P, Iunker V M, Gruntenko E V, Budker V G, Subbotin V M
Eksp Onkol. 1989;11(1):39-43.
Cells of lines of mice transplantable tumours metastasizing into the lung have been used: lung adenocarcinoma (AL), Lewis lung carcinoma (LL), melanoma B-16 (B-16), mammary tumour MMT-1 (MMT-1), malignant subline of L-cells (LS). Hybrid vesicles were obtained for each tumour. They contain fragments of cell plasmatic membranes (PM). It has been shown that AL-, LL-, LS- and B-16-liposomes were accumulated in lung, the trapping of AL- and LL-liposomes being higher than that of the other hybrid vesicles. Despite the similar dynamics and frequency of metastatic spreading into the lung for all tumours studied, no trapping of MMT-1-vesicles in the target-organ was observed. The role of specific interaction of tumour cells PM with the endothelium of the lung capillaries in the process of organotropic metastatic spreading is discussed.
肺腺癌（AL）、刘易斯肺癌（LL）、黑色素瘤B - 16（B - 16）、乳腺肿瘤MMT - 1（MMT - 1）、L细胞恶性亚系（LS）。针对每种肿瘤都获得了杂交囊泡。它们包含细胞质膜（PM）片段。已表明AL -、LL -、LS - 和B - 16 - 脂质体在肺部蓄积，AL - 和LL - 脂质体的捕获率高于其他杂交囊泡。尽管所有研究的肿瘤向肺部转移扩散的动态和频率相似，但未观察到MMT - 1囊泡在靶器官中的捕获。讨论了肿瘤细胞PM与肺毛细血管内皮在器官特异性转移扩散过程中的特异性相互作用的作用。
