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下一场避孕革命。

The next contraceptive revolution.

作者信息

Atkinson L E, Lincoln R, Forrest J D

出版信息

Fam Plann Perspect. 1986 Jan-Feb;18(1):19-26.

PMID:3803545
Abstract

The availability of modern birth control methods has wrought a veritable contraceptive revolution in both developed and developing countries over the past two decades. But concerns about safety, costly lawsuits involving current methods, as well as diverse and changing life-styles, have left the current array of contraceptives grossly inadequate to meet growing world-wide needs. Steroid implants and improved injectables, IUDs, barrier methods and sterilization devices should be widely available in the next few years. But the long-sought-after radically new methods that will constitute the next contraceptive revolution--like vaccines, a male contraceptive and a once-a-month pill--will not be developed in the foreseeable future without a massive infusion of new funds. The eight contraceptive research and development (R&D) programs that are responsible for more than half of all current product development efforts now spend about $30 million a year on contraceptive research. With an additional $23 million annually, they could considerably accelerate current research efforts and begin new ones on products that have become possible only as the result of recent scientific discoveries. Even this level of investment--representing a 75 percent increase over current expenditures by the eight groups--would probably not be sufficient to make optimum progress in the development of radically new methods. Since the pharmaceutical industry can no longer be depended upon to take the leading role that it did 20 years ago, current public-sector R&D organizations may need to expand their efforts to include most aspects of the process of contraceptive development and introduction, and new dedicated R&D centers will probably have to be established.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在过去二十年里,现代节育方法的出现给发达国家和发展中国家都带来了一场名副其实的避孕革命。但由于对安全性的担忧、涉及现有方法的高额诉讼,以及多样且不断变化的生活方式,现有的一系列避孕方法已远远无法满足全球日益增长的需求。类固醇植入剂、改良型注射剂、宫内节育器、屏障法和绝育装置有望在未来几年广泛供应。但像疫苗、男性避孕药和每月服用一次的药丸这类人们长期寻求的、将构成下一次避孕革命的全新方法,在可预见的未来,如果没有大量新资金注入,是无法研发出来的。目前负责一半以上现有产品研发工作的八个避孕研发项目,每年在避孕研究上的花费约为3000万美元。如果每年再增加2300万美元,它们就能大幅加快当前的研究工作,并启动针对那些因近期科学发现才成为可能的产品的新研究。即便如此水平的投资——意味着这八个团体的支出比目前增加75%——可能也不足以在全新方法的研发上取得最佳进展。由于不能再指望制药行业发挥其20年前所起的主导作用,当前的公共部门研发组织可能需要扩大努力范围,涵盖避孕产品研发和推广过程的大部分环节,而且可能还得设立新的专门研发中心。(摘要截选至250词)

相似文献

1
The next contraceptive revolution.下一场避孕革命。
Fam Plann Perspect. 1986 Jan-Feb;18(1):19-26.
2
[Contraceptive development--the view from the U.S.A. in the mid 80s].[避孕方法的发展——20世纪80年代中期美国的视角]
Contracept Fertil Sex (Paris). 1986 Mar;14(3):247-51.
3
Worldwide trends in funding for contraceptive research and evaluation.全球范围内避孕研究与评估的资金投入趋势。
Fam Plann Perspect. 1985 Sep-Oct;17(5):196-207.
4
Looking into the future.展望未来。
Plan Parent Rev. 1983 Summer;3(2):3-5.
5
The state of the contraceptive art.避孕技术的现状。
Plan Parent Rev. 1983;3(2):5-7.
6
Contraception today.当今的避孕方法。
Ann N Y Acad Sci. 2006 Dec;1092:1-32. doi: 10.1196/annals.1365.002.
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Introducing new contraceptives.推出新型避孕药具。
Draper Fund Rep. 1986 Dec(15):27-32.
8
Contraceptive technologies: how much choice do we really have?避孕技术:我们究竟有多少选择?
ZPG Report. 1997 Mar-Apr;29(2):4-6.
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Long-acting steroid contraceptive technology.
Health Sex. 1991 Winter;2(1):1-5, 7, 16.
10
Family planning in Viet Nam: a vigorous approach.越南的计划生育:一种积极的方法。
World Health Stat Q. 1994;47(1):36-9.

引用本文的文献

1
Contraception--problems and prospects.避孕——问题与前景
West J Med. 1988 Dec;149(6):770-1.