Department of Medical Engineering, Dongguk University College of Medicine, Goyang-si, 10326, Gyeonggi-do, Korea.
Office of Technology Transfer, National Cancer Center, Goyang-si, 10408, Gyeonggi-do, Korea.
BMC Pharmacol Toxicol. 2023 Dec 1;24(1):70. doi: 10.1186/s40360-023-00711-9.
Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical trials for respiratory diseases, it has not yet been approved for treatment. Moreover, there is limited information regarding the delivery efficiency of therapeutic antibodies via nebulizer.
In this study, the nebulization characteristics and drug delivery efficiencies were compared when immunoglobulin G (IgG) was delivered by five nebulizers using two airway models and five breathing patterns. The study confirmed that the delivered dose and drug delivery efficiency were reduced in the child model compared to those in the adult model and in the asthma pattern compared to those in the normal breathing pattern.
The NE-SM1 NEPLUS vibrating mesh nebulizer demonstrated the highest delivery efficiency when calculated as a percentage of the loading dose, whereas the PARI BOY SX + LC SPRINT (breath-enhanced) jet nebulizer had the highest delivery efficiency when calculated as a percentage of the emitted dose.
The results suggest that the total inspiration volume, output rate, and particle size should be considered when IgG nebulization is used. We, therefore, propose a method for evaluating the efficiency of nebulizer for predicting antibody drug delivery.
雾化器常用于治疗呼吸道疾病，这些疾病是发病率和死亡率的主要原因。虽然针对呼吸道疾病的抗体吸入疗法已在临床前研究和临床试验中进行了评估，但尚未被批准用于治疗。此外，关于通过雾化器输送治疗性抗体的输送效率的信息有限。
在这项研究中，使用两种气道模型和五种呼吸模式比较了五种雾化器输送免疫球蛋白 G（IgG）时的雾化特性和药物输送效率。研究证实，与成人模型相比，儿童模型中输送的剂量和药物输送效率降低，与正常呼吸模式相比，哮喘模式中的输送剂量和药物输送效率降低。
当以加载剂量的百分比计算时，NE-SM1 NEPLUS 振动网雾化器显示出最高的输送效率，而当以发射剂量的百分比计算时，PARI BOY SX + LC SPRINT（呼吸增强）射流雾化器显示出最高的输送效率。
结果表明，在使用 IgG 雾化时应考虑总吸气量、输出率和粒径。因此，我们提出了一种评估雾化器效率以预测抗体药物输送的方法。
