Chang Kyung Hwa, Moon Sang-Hyub, Oh Jin Young, Yoon Young-Soon, Gu Namyi, Lim Chi-Yeon, Park Bong Joo, Nam Ki Chang
Department of Medical Engineering, Dongguk University College of Medicine, Goyang-si, Gyeonggi-do 10326, Korea.
Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do 10326, Korea.
Pharmaceutics. 2019 Apr 19;11(4):192. doi: 10.3390/pharmaceutics11040192.
Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.
最近使用呼吸模拟器系统的报告表明，网式雾化器比喷射式雾化器能更有效地输送药物。在本研究中，通过比较喷射式雾化器和网式雾化器在小鼠体内的气溶胶药物递送效率来评估它们的性能。我们比较了四种家用雾化器：两种喷射式雾化器（带红色和蓝色喷嘴的PARI BOY SX）、一种静态网式雾化器（NE-U22）和一种振动网式雾化器（NE-SM1）。小鼠暴露于沙丁胺醇气雾剂后，通过酶联免疫吸附测定法（ELISA）评估血清和肺中沙丁胺醇的水平。PARI BOY SX中沙丁胺醇的残留量最大，为34.6%，而NE-U22和NE-SM1网式雾化器的值均小于1%。NE-U22和NE-SM1的沙丁胺醇递送效率高于PARI BOY SX，因为肺和血清的总递送量分别是PARI BOY SX的39.9%和141.7%。网式雾化器的递送效率优于喷射式雾化器。尽管喷射式雾化器能产生比本研究中使用的网式雾化器更小的气溶胶颗粒，但喷射式雾化器的输出率较低，导致沙丁胺醇递送效率较低。因此，有必要根据雾化器类型对药物递送效率进行临床验证，以避免用药过量和减少药物浪费。
