Matsuzaki Tyler, Weistuch Corey, de Graff Adam, Dill Ken A, Balázsi Gábor
Stony Brook University.
Memorial Sloan Kettering Cancer Center.
bioRxiv. 2023 Nov 21:2023.11.21.568122. doi: 10.1101/2023.11.21.568122.
As cells age, they undergo a remarkable global change: In , hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging worms, we find that the upregulated genes code for sensory proteins upstream of stress responses and downregulated genes are growth- and metabolism-related. We propose a simple mechanistic model for how such global coordination of multi-protein expression levels may be achieved by the binding of a single ligand that concentrates with age. A key implication is that a cell's own responses are part of its aging process, so unlike for wear-and-tear processes, intervention might be able to modulate these effects.
随着细胞衰老，它们会经历显著的整体变化：在衰老过程中，数百个基因过度表达，而数百个其他基因表达不足。通过对衰老蠕虫的数据进行原型建模和基因本体分析，我们发现上调的基因编码应激反应上游的感觉蛋白，而下调的基因与生长和代谢相关。我们提出了一个简单的机制模型，说明如何通过一种随年龄积累的单一配体的结合来实现多蛋白表达水平的这种整体协调。一个关键的启示是，细胞自身的反应是其衰老过程的一部分，因此与磨损过程不同，干预或许能够调节这些影响。
