Bodaghi E, Vazirian S, Madani A, Shmsa A M, Afzali H M, Elmi F
Int J Pediatr Nephrol. 1986 Jul-Sep;7(3):127-30.
Three hundred and ten children with primary nephrotic syndrome were studied since 1972. 190 patients are classified as nephrosis (61%); including minimal glomerular lesions (22.9%), diffuse mesangial proliferation (6.77%) and focal and segmental sclerosis (31.6%). Corticoresponsivity was limited: 53.75% with a higher success rate in minimal glomerular lesions: 74% versus 38% of diffuse mesangial proliferation and 42.5% focal and segmental sclerosis. Immunosuppressive drugs were used for 96 patients corticodependent or resistant. They were more effective in dependent than resistant cases 94% versus 38%. A total of 149 cases were followed (mean: 3.9 years). In the last evaluation 67% were in remission, 8.10% in chronic renal failure and 24.8% with other abnormalities.
自1972年以来，对310例原发性肾病综合征患儿进行了研究。190例患者被归类为肾病（61%）；包括微小病变性肾小球病（22.9%）、弥漫性系膜增生（6.77%）和局灶节段性硬化（31.6%）。皮质激素反应性有限：53.75%，微小病变性肾小球病的成功率较高：74%，而弥漫性系膜增生为38%，局灶节段性硬化为42.5%。96例皮质激素依赖或抵抗的患者使用了免疫抑制剂。它们在依赖型病例中比抵抗型病例更有效，分别为94%和38%。共对149例病例进行了随访（平均：3.9年）。在最后一次评估中，67%处于缓解期，8.10%处于慢性肾衰竭，24.8%有其他异常。
