Yousuf Kauser, Ibrahim Hadiza, Elbashari Mahfoud, Abouelnaga Mohamed E, Alzaabi Amani
Internal Medicine, Zayed Military Hospital, Abu Dhabi, ARE.
Neurology/Internal Medicine, Zayed Military Hospital, Abu Dhabi, ARE.
Cureus. 2023 Oct 31;15(10):e48055. doi: 10.7759/cureus.48055. eCollection 2023 Oct.
Peripheral neuropathy is a common manifestation of Eosinophilic Granulomatosis with Polyangiitis (EGPA), a rare autoimmune disorder caused by eosinophilic infiltration of multiple organs including the nervous system. Recent research has shown an association between myelin oligodendrocyte glycoprotein (MOG) antibodies and various neurologic conditions. We present a unique case of EGPA with positive MOG antibodies in the cerebrospinal fluid (CSF) in a patient presenting with peripheral neuropathy. We also highlight a few diagnostic dilemmas with EGPA and the importance of early diagnosis and appropriate treatment. Clinical, laboratory, radiological, and electrophysiologic findings are discussed.
周围神经病变是嗜酸性肉芽肿性多血管炎(EGPA)的常见表现,EGPA是一种罕见的自身免疫性疾病,由包括神经系统在内的多个器官嗜酸性粒细胞浸润引起。最近的研究表明,髓鞘少突胶质细胞糖蛋白(MOG)抗体与各种神经系统疾病之间存在关联。我们报告了1例周围神经病变患者脑脊液(CSF)中MOG抗体呈阳性的EGPA独特病例。我们还强调了EGPA的一些诊断难题以及早期诊断和适当治疗的重要性。文中讨论了临床、实验室、影像学和电生理检查结果。