一种新型的具有低免疫原性和高效力的志贺毒素 2a 中和抗体治疗药物。
A novel Shiga toxin 2a neutralizing antibody therapeutic with low immunogenicity and high efficacy.
机构信息
United States Department of Agriculture, Agricultural Research Service, Western Regional Research Center , Albany, California, USA.
U.S. Department of Energy, Oak Ridge Institute for Science and Education , Oak Ridge, Tennessee, USA.
出版信息
Antimicrob Agents Chemother. 2024 Jan 10;68(1):e0059823. doi: 10.1128/aac.00598-23. Epub 2023 Dec 4.
Abstract
Shiga toxin-producing infections are difficult to treat due to the risk of antibiotic-induced stress upregulating the production of toxins, medical treatment is consequently limited to supportive care to prevent the development of hemolytic uremic syndrome (HUS). Here, we introduce a potentially therapeutic humanized mouse monoclonal antibody (Hu-mAb 2-5) targeting Stx2a, the most common Shiga toxin subtype identified from outbreaks. We demonstrate that Hu-mAb 2-5 has low immunogenicity in healthy adults and high neutralizing efficacy , protecting mice from mortality and HUS-related tissue damage.
摘要
产志贺毒素感染由于抗生素诱导的应激增加毒素产生的风险而难以治疗，因此治疗仅限于支持性护理以预防溶血性尿毒症综合征（HUS）的发展。在这里，我们介绍了一种针对 Stx2a 的潜在治疗性人源化单克隆抗体（Hu-mAb 2-5），Stx2a 是从暴发中鉴定出的最常见的志贺毒素亚型。我们证明 Hu-mAb 2-5 在健康成年人中具有低免疫原性和高中和效力，可保护小鼠免于死亡和与 HUS 相关的组织损伤。
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