University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich.
Chimia (Aarau). 2023 Apr 26;77(4):230-234. doi: 10.2533/chimia.2023.230.
This review discusses small molecule antibiotics approved for clinical use in the time frame 2010-2022. This time span saw the approval of four synthetic antibiotics (bedaquiline, pretomanid, delafloxacin, tedizolid), nine natural product derivatives (ceftaroline fosamil, cefiderocol, plazomicin, omadacycline, eravacycline, sarecycline, lefamulin, dalbavancin, oritavancin), and one natural product (fidaxomicin).
这篇综述讨论了在 2010 年至 2022 年期间获得临床批准使用的小分子抗生素。在这段时间内，有四种合成抗生素（贝达喹啉、普托马尼德、德拉沙星、替加环素）、九种天然产物衍生物（头孢他啶磷霉素、头孢地尔科、硫酸普拉唑米星、奥马环素、依拉环素、沙雷环素、雷法莫司汀、达巴万星、奥他伐星）和一种天然产物（非达霉素）获得批准。
