Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, SAR, China; Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Neurosci Biobehav Rev. 2024 Jan;156:105501. doi: 10.1016/j.neubiorev.2023.105501. Epub 2023 Dec 6.
Low-intensity transcranial ultrasound stimulation (LITUS) is a novel non-invasive neuromodulation technique. We conducted a systematic review to evaluate current evidence on the efficacy and safety of LITUS neuromodulation. Five databases were searched from inception to May 31, 2023. Randomized controlled human trials and controlled animal studies were included. The neuromodulation effects of LITUS on clinical or pre-clinical, neurophysiological, neuroimaging, histological and biochemical outcomes, and adverse events were summarized. In total, 11 human studies and 44 animal studies were identified. LITUS demonstrated therapeutic efficacy in neurological disorders, psychiatric disorders, pain, sleep disorders and hypertension. LITUS-related changes in neuronal structure and cortical activity were found. From histological and biochemical perspectives, prominent findings included suppressing the inflammatory response and facilitating neurogenesis. No adverse effects were reported in controlled animal studies included in our review, while reversible headache, nausea, and vomiting were reported in a few human subjects. Overall, LITUS alleviates various symptoms and modulates associated brain circuits without major side effects. Future research needs to establish a solid therapeutic framework for LITUS.
低强度经颅超声刺激（LITUS）是一种新型的非侵入性神经调节技术。我们进行了一项系统评价，以评估 LITUS 神经调节的当前疗效和安全性证据。从建库到 2023 年 5 月 31 日，我们在五个数据库中进行了检索。纳入了随机对照人体试验和对照动物研究。总结了 LITUS 对临床或临床前、神经生理学、神经影像学、组织学和生物化学结果以及不良事件的神经调节作用。共确定了 11 项人体研究和 44 项动物研究。LITUS 在神经障碍、精神障碍、疼痛、睡眠障碍和高血压方面显示出治疗效果。发现 LITUS 引起了神经元结构和皮质活动的变化。从组织学和生物化学的角度来看，突出的发现包括抑制炎症反应和促进神经发生。我们的综述中纳入的对照动物研究未报告不良影响，而少数人体受试者报告了可逆性头痛、恶心和呕吐。总体而言，LITUS 缓解了各种症状，并调节了相关的大脑回路，没有明显的副作用。未来的研究需要为 LITUS 建立一个坚实的治疗框架。
