Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Department of Psychology & Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, TN.
J Clin Oncol. 2024 Feb 20;42(6):686-695. doi: 10.1200/JCO.23.01747. Epub 2023 Dec 8.
Tumors of CNS are common in adolescents and young adults (AYAs). As the second leading cause of cancer-related death, CNS tumors in AYAs require improved clinical management. In this review, we discussed the current diagnostic approaches and recommended management strategies for malignant tumors in adult-type (IDH-mutant gliomas) and pediatric-type gliomas (pediatric high-grade gliomas), ependymoma and medulloblastoma, which commonly occur in AYAs. The impact of advanced molecular diagnostic approaches on the understanding of tumor biology of AYA CNS tumors is emphasized. To enhance participation in clinical trials, which poses a unique challenge in AYAs with CNS tumors, we propose encouraging referrals to neuro-oncology specialty care and improving collaboration between oncologists who care for both pediatric and adult patients. This will ensure better representation of AYA patients in research studies. Finally, we discussed the importance of considering neurocognitive and psychological function in AYAs with CNS tumor.
中枢神经系统肿瘤在青少年和年轻人（AYAs）中较为常见。作为癌症相关死亡的第二大原因，AYAs 中的中枢神经系统肿瘤需要改进临床管理。在这篇综述中，我们讨论了成人型（IDH 突变型神经胶质瘤）和儿童型神经胶质瘤（儿童高级别神经胶质瘤）、室管膜瘤和髓母细胞瘤等常见于 AYA 的恶性肿瘤的当前诊断方法和推荐的管理策略。强调了先进的分子诊断方法对 AYA 中枢神经系统肿瘤肿瘤生物学的理解的影响。为了加强临床试验的参与，这对患有中枢神经系统肿瘤的 AYA 提出了独特的挑战，我们建议鼓励向神经肿瘤学专业护理转诊，并改善同时照顾儿科和成年患者的肿瘤学家之间的合作。这将确保在研究中更好地代表 AYA 患者。最后，我们讨论了在患有中枢神经系统肿瘤的 AYA 中考虑神经认知和心理功能的重要性。
