Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga - Kaunas, Lithuania.
Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga - Kaunas, Lithuania.
Physiol Behav. 2024 Feb 1;274:114429. doi: 10.1016/j.physbeh.2023.114429. Epub 2023 Dec 6.
Fatigue and sleep disturbances are important symptoms of anxiety and mood disorders (AMD). Studies about the relationship between these variables usually rely on self-report assessments. Therefore, the aim of our exploratory study was to investigate the independent correlations between subjective and objective fatigue and sleep characteristics in individuals with AMD.
In sum, 233 individuals with AMD attending a stress-related disorders day care unit (78.5 % females, mean age 39.0 years old) participated in a cross-sectional study. Participants completed the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Multidimensional Fatigue Inventory-20, and Pittsburgh Sleep Quality Index self-report questionnaires, as well as an exercise capacity workload test for assessing objective fatigue and polysomnography monitoring for evaluation of sleep structure.
In individuals with AMD, exercise capacity workload was associated with lower percent of stage 1 sleep (β = - 0.17, p = 0.006), REM latency (β = -0.13, p = 0.042), and wake after sleep onset (β = -0.12, p = 0.039). General fatigue was associated with a higher percent of body movements (β = 0.12, p = 0.047), as well as mental fatigue was associated with a higher percent of body movements (β = 0.13, p = 0.029), and a higher score on the PSQI (β = 0.21, p = 0.002).
Objective sleep characteristics were associated with objective assessment of fatigue, while subjective sleep quality was associated with subjectively assessed mental fatigue.
疲劳和睡眠障碍是焦虑和情绪障碍（AMD）的重要症状。关于这些变量之间关系的研究通常依赖于自我报告评估。因此，我们探索性研究的目的是调查 AMD 个体主观和客观疲劳与睡眠特征之间的独立相关性。
共有 233 名患有 AMD 的个体参加了与应激相关障碍日间护理单位的横断面研究（78.5%为女性，平均年龄 39.0 岁）。参与者完成了患者健康问卷-9、广泛性焦虑障碍-7、多维疲劳量表-20 和匹兹堡睡眠质量指数自评问卷，以及评估客观疲劳的运动能力工作量测试和评估睡眠结构的多导睡眠图监测。
在 AMD 个体中，运动能力工作量与 1 期睡眠百分比降低（β=-0.17，p=0.006）、快速眼动潜伏期（β=-0.13，p=0.042）和睡眠后觉醒（β=-0.12，p=0.039）相关。一般疲劳与身体运动百分比升高有关（β=0.12，p=0.047），精神疲劳与身体运动百分比升高有关（β=0.13，p=0.029），以及 PSQI 评分升高有关（β=0.21，p=0.002）。
客观睡眠特征与客观疲劳评估相关，而主观睡眠质量与主观评估的精神疲劳相关。
