Liu Wei K, Kothare Sanjeev, Jain Sejal
Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital, Cincinnati, OH.
Division of Pediatric Neurology, Department of Pediatrics, Cohen Children's Medical Center, New York, NY.
Semin Pediatr Neurol. 2023 Dec;48:101087. doi: 10.1016/j.spen.2023.101087. Epub 2023 Sep 24.
The relationship between sleep and epilepsy is both intimate and bidirectional. The molecular mechanisms which control circadian rhythm and the sleep/wake cycle are dysregulated in epileptogenic tissue and are themselves effected by molecular pathways for epilepsy. Sleep affects the frequency of interictal epileptiform discharges and recent research has raised new questions regarding the impact of discharges on sleep function and cognition. Epileptiform discharges themselves affect sleep architecture and increase the risk of sleep disorders. Several sleep-related epilepsy syndromes have undergone changes in their classification which highlights their intimate relationship to sleep and novel screening tools have been developed to help clinicians better differentiate epileptic seizures from sleep-related paroxysmal events. Improving sleep and addressing sleep disorders has been associated with improved seizure control and increased well-being in people with epilepsy. These interactions are discussed in detail in this review.
睡眠与癫痫之间的关系既密切又呈双向性。控制昼夜节律以及睡眠/觉醒周期的分子机制在致痫组织中失调，且其自身也受癫痫分子通路的影响。睡眠会影响发作间期癫痫样放电的频率，最近的研究就放电对睡眠功能和认知的影响提出了新问题。癫痫样放电本身会影响睡眠结构并增加睡眠障碍的风险。几种与睡眠相关的癫痫综合征在分类上已发生变化，这凸显了它们与睡眠的密切关系，并且已开发出新的筛查工具来帮助临床医生更好地将癫痫发作与睡眠相关的阵发性事件区分开来。改善睡眠和解决睡眠障碍与癫痫患者更好的发作控制及更高的幸福感相关。本综述将详细讨论这些相互作用。
