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雏菊中的生物活性化合物 ()。

(Bio)active Compounds in Daisy Flower ().

机构信息

Chair of Food Chemistry and Molecular Sensory Science, Technical University of Munich, Lise-Meitner-Str. 34, 85354 Freising, Germany.

出版信息

Molecules. 2023 Nov 22;28(23):7716. doi: 10.3390/molecules28237716.

DOI:10.3390/molecules28237716
PMID:38067445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10707873/
Abstract

The common daisy () belongs to the family Asteraceae and, in recent years, some new research has been published on the bioactive compounds and biological activities of its extracts. In 2014, the knowledge was partially summarized, but several new studies have been published in the last nine years. In addition, the substances were tabularly consolidated to give a comprehensive overview of over 310 individual components, compound classes, and bioactivities, as well as their accurate plant organ origin. The latest results have shown that the plant has antioxidative, antimicrobial, anticancerogenic, wound healing, antidepressive, anxiolytic, nephroprotective, and insulin mimetic effects, as well as an effect on lipid metabolism. Some studies in the field of homeopathy were also listed. Ideally, a biological effect and one or several compound(s) can be correlated. However, the compounds of the extracts used have often been qualified and quantified, but it remains unclear which of these substances have an activity. The works often stick at the level of the crude extract or a fraction, but not at a single purified and tested compound and, consequently, they are hampered by a missing comprehensive bioactivity workflow. This review provides a critical overview and gaps and offers a basis for further research in this area.

摘要

普通雏菊()属于菊科植物,近年来,关于其提取物的生物活性化合物和生物活性的新研究已经发表。2014 年,该知识得到了部分总结,但在过去九年中又发表了几项新的研究。此外,还对物质进行了表格化整合,以便全面概述超过 310 种单独的成分、化合物类别和生物活性及其准确的植物器官来源。最新的结果表明,该植物具有抗氧化、抗菌、抗癌、伤口愈合、抗抑郁、抗焦虑、肾保护和胰岛素模拟作用,以及对脂质代谢的影响。还列出了顺势疗法领域的一些研究。理想情况下,可以将生物学效应和一种或几种化合物相关联。然而,所使用的提取物中的化合物通常经过定性和定量,但仍不清楚哪些物质具有活性。这些工作往往停留在粗提物或馏分的水平,而不是单一的纯化和测试化合物,因此它们受到缺乏全面生物活性工作流程的阻碍。本文综述提供了批判性的概述和差距,并为该领域的进一步研究提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe8/10707873/a7a5f823cbca/molecules-28-07716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe8/10707873/294ed310c252/molecules-28-07716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe8/10707873/a7a5f823cbca/molecules-28-07716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe8/10707873/294ed310c252/molecules-28-07716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe8/10707873/a7a5f823cbca/molecules-28-07716-g002.jpg

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本文引用的文献

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Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects.延龄草提取物可减轻 UVA 诱导的角质形成细胞损伤:光保护和免疫调节作用。
J Photochem Photobiol B. 2021 Aug;221:112247. doi: 10.1016/j.jphotobiol.2021.112247. Epub 2021 Jun 19.
2
Insulin Mimetic Properties of Extracts Prepared from .从 中制备的提取物的胰岛素模拟特性。
Molecules. 2018 Oct 11;23(10):2605. doi: 10.3390/molecules23102605.
3
An In Ovo Model for Testing Insulin-mimetic Compounds.一种用于测试胰岛素模拟化合物的鸡胚内模型。
J Vis Exp. 2018 Apr 23(134):57237. doi: 10.3791/57237.
4
Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.雏菊花朵中的酰化齐墩果烷型三萜皂苷对人消化道癌细胞系具有抗增殖活性。
J Nat Med. 2016 Jul;70(3):435-51. doi: 10.1007/s11418-016-0998-9. Epub 2016 May 13.
5
Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis.来自雏菊花朵的具有促进胶原蛋白合成活性的齐墩果烷型三萜皂苷。
Phytochemistry. 2015 Aug;116:203-212. doi: 10.1016/j.phytochem.2015.05.011. Epub 2015 May 28.
6
Isolation of an oleanane-type saponin active from Bellis perennis through antitumor bioassay-guided procedures.通过抗肿瘤生物活性导向法从雏菊中分离出一种具有活性的齐墩果烷型皂苷。
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7
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8
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9
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