一种用于测定洗必泰的新型聚合膜传感器。

A Novel Polymeric Membrane Sensor for Chlorhexidine Determination.

机构信息

Department of Analytical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Square 3, 20-031 Lublin, Poland.

出版信息

Sensors (Basel). 2023 Nov 29;23(23):9508. doi: 10.3390/s23239508.

DOI:10.3390/s23239508

PMID:38067881

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10708652/

Abstract

In the present work, potentiometric sensors with polymer membranes used for chlorhexidine (CHXD) determination were developed. The polymer membranes were plasticized with bis(2-ethylheksyl)sebacate (DOS) or 2-nitrophenyloctyl ether (-NPOE). The active compounds used in the membrane were cyclodextrins, crown ethers, and ion exchangers. The best-constructed electrode was based on neutral heptakis(2,3,6-tri-O-benzoyl)--cyclodextrin with lipophilic salt (KTpClBP)-potassium tetrakis(4-chlorophenyl) borate-dissolved in plasticizer, DOS. The presented electrode is characterized by an average cationic slope of 30.9 ± 2.9 mV decade within a linear range of 1 × 10 to 1 × 10 mol × L, while the value of the correlation coefficient is 0.9970 ± 0.0026. The response time was about 5 s when increasing the sample concentration and about 10 s when diluting the sample. The electrode potential is independent of the pH within a range of 4.0-9.5. The polymeric membrane sensor was successfully applied for assays of chlorhexidine digluconate in pure samples and pharmaceutical samples. The relative error from three replicate measurements was determined to be 1.1%. and the accuracy was RSD = 0.3-1.1%.

摘要

在本工作中，开发了用于氯己定（CHXD）测定的带有聚合物膜的电位传感器。聚合物膜用双（2-乙基己基）癸二酸酯（DOS）或 2-硝基苯辛醚（-NPOE）增塑。用于膜中的活性化合物是环糊精、冠醚和离子交换剂。构建最好的电极是基于中性 heptakis(2,3,6-tri-O-benzoyl)--cyclodextrin 与亲脂盐（KTpClBP）-四（对氯苯基）硼酸钾溶解在增塑剂 DOS 中。所提出的电极的特征在于在 1×10 至 1×10 mol×L 的线性范围内平均阳离子斜率为 30.9±2.9 mV decade，而相关系数的值为 0.9970±0.0026。当增加样品浓度时，响应时间约为 5 s，当稀释样品时，响应时间约为 10 s。电极电位在 4.0-9.5 范围内与 pH 值无关。聚合物膜传感器成功地应用于纯样品和药物样品中葡萄糖酸氯己定的测定。三个重复测量的相对误差确定为 1.1%，准确度为 RSD=0.3-1.1%。