Science and Technology, Application and Research Center, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Department of Chemistry, Tokat Gaziosmanpasa University, Tokat, Turkey.
Crit Rev Anal Chem. 2022;52(4):768-779. doi: 10.1080/10408347.2020.1825065. Epub 2020 Sep 29.
Potentiometry is extensively studied by researchers as one of the electrochemical methods due to its multiple advantages. Until today, thousands of potentiometric sensors have been developed and applied successfully in many fields such as medicine, environmental monitoring, agriculture, industry and pharmaceutical sciences. Clinical drug analyses and determination of drugs in biological samples are highly important from a medical point of view. These analyses are carried out using various analytical devices including potentiometric sensors. These potentiometric sensors are superior to other devices in terms of several performance parameters, and thus present a good alternative for researchers. Using potentiometric sensors, very successful results in the identification of drug molecules in body fluids have been obtained and reported in the literature up to now. In this study, we review potentiometry-based sensors developed for the determination of drug molecules in various biological samples such as blood serum and urine, and touch upon their performance features in these applications.
电位法由于其诸多优点而被研究人员广泛研究为电化学方法之一。迄今为止，已经开发出数千种电位传感器，并成功应用于医学、环境监测、农业、工业和药物科学等多个领域。从医学角度来看，临床药物分析和生物样本中药物的测定非常重要。这些分析是使用各种分析设备，包括电位传感器来进行的。这些电位传感器在多个性能参数方面优于其他设备，因此为研究人员提供了一个很好的选择。迄今为止，使用电位传感器已经在体液中药物分子的鉴定方面取得了非常成功的结果，并在文献中有所报道。在本研究中，我们综述了用于测定各种生物样品（如血清和尿液）中药物分子的基于电位法的传感器，并探讨了它们在这些应用中的性能特点。
