Nussbaum Robin, Robinson Kye, Soda Yoshiki, Bakker Eric
Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva.
Chimia (Aarau). 2022 Apr 27;76(4):284-287. doi: 10.2533/chimia.2022.284.
Heparin quantification at the point of care has been of medical interest for years but a suitable point of care measurement method for whole blood is still elusive. Our group has recently developed a nanoparticle-based optical sensor for protamine that allows for heparin quantification in plasma. This work discusses the effect of the transducing-dye structure and the promise of embedding the sensors in an agarose gel for avoiding red blood cell interference.
即时检测肝素定量多年来一直是医学关注的焦点，但一种适用于全血的即时检测方法仍未找到。我们团队最近开发了一种基于纳米颗粒的鱼精蛋白光学传感器，可用于血浆中肝素的定量。本文讨论了传感染料结构的影响以及将传感器嵌入琼脂糖凝胶以避免红细胞干扰的前景。
