Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China; School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan, China; Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China; School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Prev Med. 2024 Feb;179:107796. doi: 10.1016/j.ypmed.2023.107796. Epub 2023 Dec 7.
Colorectal cancer (CRC) is one of the most common cancers worldwide, and recent studies have found that CRC patients are at increased risk for cardiovascular disease (CVD). This study aimed to investigate competing causes of death and prognostic factors among a large cohort of CRC patients and to describe cardiovascular-specific mortality in relation to the US standard population.
This registry-based cohort study identified patients diagnosed with CRC between 1973 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database in the US. Cumulative mortality functions, conditional standardized mortality ratios, and cause-specific hazard ratios were calculated.
Of the 563,298 eligible CRC patients included in this study, 407,545 died during the follow-up period. CRC was the leading cause of death, accounting for 49.8% of all possible competing causes of death. CVD was the most common non-cancer cause of death, accounting for 17.8% of total mortality. This study found that CRC patients have a significantly increased risk of cardiovascular-specific mortality compared to the US standard population, with the risk increasing with age and extended survival time.
This study highlights the need to develop multidisciplinary prevention and management strategies for CRC and CVD to improve CRC patients' survival and quality of life.
结直肠癌（CRC）是全球最常见的癌症之一，最近的研究发现 CRC 患者患心血管疾病（CVD）的风险增加。本研究旨在调查大型 CRC 患者队列的竞争死亡原因和预后因素，并描述与美国标准人群相关的心血管特异性死亡率。
本基于登记的队列研究从美国监测、流行病学和最终结果（SEER）数据库中确定了 1973 年至 2015 年间诊断为 CRC 的患者。计算了累积死亡率函数、条件标准化死亡率比和原因特异性危险比。
在这项研究中，纳入了 563298 名符合条件的 CRC 患者，其中 407545 人在随访期间死亡。CRC 是主要的死亡原因，占所有可能竞争死亡原因的 49.8%。CVD 是最常见的非癌症死亡原因，占总死亡率的 17.8%。本研究发现，CRC 患者的心血管特异性死亡率明显高于美国标准人群，且风险随年龄和生存时间的延长而增加。
本研究强调需要制定 CRC 和 CVD 的多学科预防和管理策略，以提高 CRC 患者的生存率和生活质量。
