Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Vet Anaesth Analg. 2024 Jan;51(1):60-63. doi: 10.1016/j.vaa.2023.11.008. Epub 2023 Nov 24.
To compare recovery times of sugammadex with spontaneous recovery from rocuronium-induced neuromuscular block (NMB) in dogs.
Retrospective, unmatchedcase-control study.
A total of 10 dogs administered sugammadex and 10 dogs recovering spontaneously from rocuronium-induced NMB.
Files of dogs administered rocuronium between March and August 2023 were inspected. The train-of-four (TOF) count at the time of sugammadex administration and the time between administration and TOF ratio >90% (recovery time) were recorded. The recovery time for those not administered reversal agents was considered from the first TOF value >0 until TOF ratio >90%. The dose of sugammadex and the cumulative dose of rocuronium were recorded. Rocuronium doses and recovery times were compared using Mann-Whitney tests. The coefficient of determination (R) between the cumulative rocuronium dose and sugammadex dose and the recovery time were calculated.
Dogs in the sugammadex and spontaneous recovery groups were administered intravenously (IV) 0.76 (0.4-2.6) and 0.61 (0.3-2.9) mg kg of rocuronium, respectively (p = 0.325). Recovery time after 3.9 (2.9-5.5) mg kg of sugammadex IV was 1 (1-3) minutes and was 20 (10-35) min for spontaneous recovery (p < 0.0001). The R for rocuronium and sugammadex doses and recovery times were 0.19 (p = 0.2) and 0.012 (p = 0.758).
Sugammadex 2.9-5.5 mg kg reversed moderate (TOF count 1-3) or deep (TOF count 0) rocuronium-induced NMB within 3 minutes, substantially faster than spontaneous recovery.
比较舒更葡糖钠与罗库溴铵诱导的神经肌肉阻滞（NMB）自然恢复的恢复时间。
回顾性、非匹配病例对照研究。
共纳入 10 只给予舒更葡糖钠和 10 只罗库溴铵诱导的 NMB 自然恢复的狗。
检查 2023 年 3 月至 8 月期间给予罗库溴铵的狗的档案。记录舒更葡糖钠给药时的四个成串刺激（TOF）计数和从给药到 TOF 比值>90%（恢复时间）的时间。未给予逆转剂的恢复时间从第一个 TOF 值>0 开始计算，直到 TOF 比值>90%。记录舒更葡糖钠的剂量和罗库溴铵的累积剂量。使用 Mann-Whitney 检验比较罗库溴铵剂量和恢复时间。计算罗库溴铵累积剂量与舒更葡糖钠剂量和恢复时间之间的决定系数（R）。
舒更葡糖钠组和自然恢复组狗分别静脉内（IV）给予 0.76（0.4-2.6）和 0.61（0.3-2.9）mg/kg 罗库溴铵（p=0.325）。给予 3.9（2.9-5.5）mg/kg 舒更葡糖钠 IV 后，恢复时间为 1（1-3）分钟，自然恢复时间为 20（10-35）分钟（p<0.0001）。罗库溴铵和舒更葡糖钠剂量与恢复时间的 R 为 0.19（p=0.2）和 0.012（p=0.758）。
2.9-5.5mg/kg 舒更葡糖钠可在 3 分钟内逆转中度（TOF 计数 1-3）或深度（TOF 计数 0）罗库溴铵诱导的 NMB，速度明显快于自然恢复。
