Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Vet Anaesth Analg. 2023 Nov;50(6):485-491. doi: 10.1016/j.vaa.2023.08.002. Epub 2023 Aug 5.
To investigate the reversal effect of sugammadex on neuromuscular blockade induced by a single bolus of rocuronium in dogs under alfaxalone anesthesia.
Randomized, prospective, crossover experimental study.
A group of six adult Beagle dogs (three females and three males), weighing 11.3-15.8 kg and aged 6-8 years, were used.
Dogs were anesthetized twice with a 1.25 times minimum infusion rate of alfaxalone, with a washout period of at least 14 days between experiments. Neuromuscular function was monitored using acceleromyography with train-of-four (TOF) stimulation of the peroneal nerve. After recording the control TOF ratio (TOFRC), rocuronium (0.5 mg kg) was administered intravenously. Subsequently, sugammadex (4 mg kg) or an equal volume of saline (control treatment) was administered intravenously when the TOF count returned from 0 to 1 after neuromuscular blockade. Time from rocuronium injection to TOF count = 0 (onset time), time from TOF count = 0 to TOF count = 1 (maximum blockade period), time of first twitch amplitude recovery from 0.25 to 0.75 (recovery index), and time from sugammadex or saline administration to TOF ratio/TOFRC ≥ 0.9 (recovery time) were recorded.
The onset time and maximum blockade duration did not differ between sugammadex treatment [1.2 (0.7-1.5) minutes and 9.9 (6.3-10.5) minutes, respectively] and control treatment [median (range); 1.0 (0.7-1.1) minutes and 9.9 (8.8-11.5) minutes, respectively] (p = 0.219 and 0.844, respectively). Recovery index was 0.5 (0.3-0.7) minutes in sugammadex treatment, which was shorter than that in control treatment [4.5 (3.7-4.9) minutes] (p = 0.031). Recovery time was 0.8 (0.5-2.8) minutes in sugammadex treatment, which was shorter than that in control treatment [10.5 (6.8-14.3) minutes] (p = 0.031).
Rocuronium-induced neuromuscular blockade was effectively reversed by sugammadex in dogs anesthetized with alfaxalone.
研究在氟烷麻醉下，单次罗库溴铵推注后，琥珀酸舒更葡糖钠对神经肌肉阻滞的逆转作用。
随机、前瞻性、交叉实验研究。
一组 6 只成年比格犬（3 只雌性，3 只雄性），体重 11.3-15.8kg，年龄 6-8 岁。
用氟烷以 1.25 倍最低输注率麻醉犬 2 次，两次实验之间的洗脱期至少为 14 天。使用胫神经四成串刺激（TOF）通过加速肌描记法监测神经肌肉功能。记录对照 TOF 比（TOFRC）后，静脉注射罗库溴铵（0.5mg/kg）。随后，当神经肌肉阻滞后 TOF 计数从 0 恢复到 1 时，给予琥珀酸舒更葡糖钠（4mg/kg）或等容量生理盐水（对照治疗）。记录从罗库溴铵注射到 TOF 计数=0（起始时间）、从 TOF 计数=0 到 TOF 计数=1（最大阻滞时间）、从第 1 个颤搐幅度恢复到 0.25 到 0.75（恢复指数）的时间以及从琥珀酸舒更葡糖钠或生理盐水给药到 TOF 比/TOFRC≥0.9（恢复时间）的时间。
琥珀酸舒更葡糖钠治疗组[1.2（0.7-1.5）分钟和 9.9（6.3-10.5）分钟]与对照组[中位数（范围）；1.0（0.7-1.1）分钟和 9.9（8.8-11.5）分钟]的起始时间和最大阻滞时间无差异（p=0.219 和 0.844）。琥珀酸舒更葡糖钠治疗组的恢复指数为 0.5（0.3-0.7）分钟，短于对照组[4.5（3.7-4.9）分钟]（p=0.031）。琥珀酸舒更葡糖钠治疗组的恢复时间为 0.8（0.5-2.8）分钟，短于对照组[10.5（6.8-14.3）分钟]（p=0.031）。
氟烷麻醉下，琥珀酸舒更葡糖钠可有效逆转罗库溴铵引起的神经肌肉阻滞。
