Fleck C, Bartha J, Kersten L, Hably C, Bräunlich H
Arch Int Pharmacodyn Ther. 1981 Jul;252(1):133-8.
Repeated administration of cyclopenthiazide enhances renal PAH excretion in rats. In the 1st hr after an acute PAH load the renal excretion of PAH is doubled compared with controls. Haemodynamic measurements show that this acute PAH load is related to an increase in renal blood flow, in particular to a distinct increase in blood flow in the renal cortex. This increase in renal blood flow and in intrarenal blood distribution is higher than in stimulated rats. The increase in renal excretion of PAH is stimulated rats is not connected with an increase in renal blood flow. After an acute PAH load an additional increase in renal blood flow in stimulated rats could not be observed as compared with non stimulated control rats.
重复给予环戊噻嗪可增强大鼠肾脏对对氨基马尿酸（PAH）的排泄。在急性给予PAH负荷后的第1小时，PAH的肾脏排泄量与对照组相比增加了一倍。血流动力学测量表明，这种急性PAH负荷与肾血流量增加有关，特别是肾皮质血流量明显增加。这种肾血流量和肾内血液分布的增加高于受刺激的大鼠。受刺激大鼠中PAH肾脏排泄量的增加与肾血流量的增加无关。与未受刺激的对照大鼠相比，在急性给予PAH负荷后，未观察到受刺激大鼠的肾血流量有额外增加。
