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长链非编码RNA作为竞争性内源RNA在卵巢生理过程及相关疾病中的功能作用。

The functional role of lncRNAs as ceRNAs in both ovarian processes and associated diseases.

作者信息

Usman Muhammad, Li Ai, Wu Dan, Qinyan Yang, Yi Lin Xiao, He Guiqiong, Lu Hong

机构信息

Department of Plastic and Reconstructive Surgery, Central Hospital Affiliated to Chongqing University of Technology, Gonglian yicun No.1 street lijiatuo, Banan district, Chongqing, 400054, PR China.

Department of Postdoctoral Research Workstation, The Seventh People's Hospital of Chongqing, Chongqing, PR China.

出版信息

Noncoding RNA Res. 2023 Nov 18;9(1):165-177. doi: 10.1016/j.ncrna.2023.11.008. eCollection 2024 Mar.

Abstract

Long non-coding RNAs (lncRNAs) have attracted significant scientific attention due to their central role in regulating gene expression and their profound impact on the intricate mechanisms of ovarian function. These versatile molecules exert their influence through various mechanisms, including the coordination of transcription processes, modulation of post-transcriptional events, and the shaping of epigenetic landscapes. Furthermore, lncRNAs function as competitive endogenous RNAs (ceRNAs), engaging in intricate interactions with microRNAs (miRNAs) to finely adjust the expression of target genes. The intricate lncRNA-miRNA-mRNA network serves as a crucial determinant in governing the multifaceted physiological functions of the ovaries. It holds substantial potential in unraveling the causes and progression of reproductive disorders and, importantly, in identifying new therapeutic targets and diagnostic markers for these conditions. A comprehensive comprehension of lncRNAs and their ceRNA activities within the domain of ovarian biology could potentially lead to groundbreaking advancements in clinical interventions and management strategies. This exploration of lncRNAs and their intricate involvement in the regulatory framework provides an extensive platform for deciphering the complex nature of ovarian physiology and pathology. The ongoing progress in this field, which encompasses in-depth investigations into the functional roles of specific lncRNAs, the elucidation of their complex interactions with miRNAs, and the comprehensive profiling of their expression patterns, holds the promise of making significant contributions to our understanding of ovarian biology and reproductive disorders. Ultimately, these breakthroughs will have wide-ranging translational implications, paving the way for the development of precision therapies and personalized medicine strategies to address the myriad challenges in the realm of reproductive health.

摘要

长链非编码RNA(lncRNAs)因其在调节基因表达中的核心作用以及对卵巢功能复杂机制的深远影响而备受科学界关注。这些多功能分子通过多种机制发挥作用,包括协调转录过程、调节转录后事件以及塑造表观遗传景观。此外,lncRNAs作为竞争性内源性RNA(ceRNAs),与微小RNA(miRNAs)进行复杂的相互作用,以精细调节靶基因的表达。复杂的lncRNA-miRNA-mRNA网络是决定卵巢多方面生理功能的关键因素。它在揭示生殖障碍的原因和进展方面具有巨大潜力,重要的是,在识别这些病症的新治疗靶点和诊断标志物方面也具有巨大潜力。全面了解卵巢生物学领域内的lncRNAs及其ceRNA活性,可能会在临床干预和管理策略方面带来突破性进展。对lncRNAs及其在调控框架中的复杂参与的探索,为解读卵巢生理和病理的复杂本质提供了一个广阔的平台。该领域的持续进展,包括对特定lncRNAs功能作用的深入研究、对其与miRNAs复杂相互作用的阐明以及对其表达模式的全面分析,有望为我们对卵巢生物学和生殖障碍的理解做出重大贡献。最终,这些突破将具有广泛的转化意义,为开发精准疗法和个性化医疗策略铺平道路,以应对生殖健康领域的众多挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b319/10709095/2e19988ae952/gr1.jpg

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