Wakabayashi I, Hatake K, Kimura N, Kakishita E, Nagai K
Life Sci. 1987 Feb 16;40(7):643-8. doi: 10.1016/0024-3205(87)90265-7.
The role of the vascular endothelium in the contractile response of aortas from streptozotocin-induced diabetic rats was investigated using selected agents. Contractile response to KCl was not affected by removal of the endothelium in both diabetic and control groups, but was diminished in the diabetic rats compared to the control rats. Contractile response to clonidine markedly increased after removal of the endothelium in the control group, with the increment being less in the diabetic group. After removal of the endothelium, contractile response to clonidine was poorer in the diabetic group than the control group. Vascular relaxation induced by acetylcholine disappeared when the endothelium was removed in both diabetic and control groups. The degree of reaction to acetylcholine did not significantly differ between the two groups. These results suggest that in diabetic rats, abnormality of the endothelium-dependent vascular relaxation is specific for alpha 2 receptor while that of the vascular smooth muscle reactivity is not receptor-specific.
使用特定药物研究了血管内皮在链脲佐菌素诱导的糖尿病大鼠主动脉收缩反应中的作用。糖尿病组和对照组中，去除内皮后对氯化钾的收缩反应均未受影响，但与对照组相比，糖尿病大鼠的该反应减弱。对照组去除内皮后对可乐定的收缩反应显著增强，糖尿病组的增幅较小。去除内皮后，糖尿病组对可乐定的收缩反应比对照组差。糖尿病组和对照组去除内皮后，乙酰胆碱诱导的血管舒张均消失。两组对乙酰胆碱的反应程度无显著差异。这些结果表明，在糖尿病大鼠中，内皮依赖性血管舒张异常对α2受体具有特异性，而血管平滑肌反应性异常则不具有受体特异性。
