[Effect of blood flow inhibition in tumors on the effectiveness of hyperglycemia and hyperthermia when used following radiation].

The role of tumor blood supply inhibition associated with hyperthermia (HT) and short-term hyperglycemia (SH) combined with HT in enhancement of antitumor action of x-ray radiation was assessed in experiments on solid Ehrlich carcinoma in mice. It was shown that blood flow inhibition assessed by 133Xe clearance, and tumor growth delay were more pronounced after irradiation at a dose of 10 Gy with subsequent SH and HT at 43 degrees C for 30 min as compared to a dose of 15 Gy combined with HT at 44 degrees C for 30 min. Both schemes showed correlation between a degree of blood supply damage in some tumors and the efficacy of their therapy. The authors suggest a significant role of blood flow inhibition in tumors in postradiation HT and especially HT in a background of SH for increasing antitumor effect of irradiation. The assessment of tumor blood supply inhibition is possible to predict the efficacy of SH and HT in radiation therapy.