Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), CNRS UMR 6302, 9, avenue Alain Savary, Dijon 21078, France.
Department of Chemistry, The University of Western Ontario, London, ON N6A 5B7, Canada.
Chem Commun (Camb). 2024 Jan 4;60(4):424-427. doi: 10.1039/d3cc05155b.
Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.
使用小分子（配体）稳定 DNA/RNA 四链体（G4s）已被证明是破译 G4 生物学的有效策略。颇具讽刺意味的是，这种研究也突显了寻找能够破坏 G4 的分子以解决与 G4 相关的细胞功能障碍的必要性。我们在此报告定性和定量研究，验证了 PhpC 这种先导化合物在人类细胞中破坏 G4-RNA 的特性。
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