Sharma Shubham, Hassan Muhammad Yusuf, Barbhuiya Noman Hanif, Mansukhbhai Ramolia Harshit, Shukla Chinmayee, Singh Deepshikha, Datta Bhaskar
Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, 382055, India.
Department of Electrical Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, 382055, India.
Sci Data. 2025 May 23;12(1):849. doi: 10.1038/s41597-025-05176-5.
Dysregulated expression of long non-coding RNAs (lncRNAs) in cancer contributes to various hallmarks of the disease, presenting novel opportunities for diagnosis and therapy. G-quadruplexes (G4s) within lncRNAs have gained attention recently; however, their systematic evaluation in cancer biology is yet to be performed. In this work, we have formulated a comprehensive dataset integrating experimentally-validated associations between lncRNAs and cancer, and detailed predictions of their G4-forming potential. The dataset categorizes predicted G4-motifs into anticipated G4 types (2 G, 3 G, and 4 G) and provides information about the subcellular localization of the corresponding lncRNAs. It describes lncRNA-RNA and lncRNA-protein interactions, together with the RNA G4-binding capabilities of these proteins. The dataset facilitates the investigation of G4-mediated lncRNA functions in diverse human cancers and provides distinctive leads about G4-mediated lncRNA-protein interactions.
长链非编码RNA（lncRNA）在癌症中的表达失调促成了该疾病的各种特征，为诊断和治疗带来了新的机遇。lncRNA中的G-四链体（G4s）最近受到了关注；然而，它们在癌症生物学中的系统评估尚未进行。在这项工作中，我们构建了一个综合数据集，整合了lncRNA与癌症之间经过实验验证的关联，以及对其形成G4潜力的详细预测。该数据集将预测的G4基序分类为预期的G4类型（2G、3G和4G），并提供了相应lncRNA亚细胞定位的信息。它描述了lncRNA-RNA和lncRNA-蛋白质相互作用，以及这些蛋白质的RNA G4结合能力。该数据集有助于研究G4介导的lncRNA在多种人类癌症中的功能，并提供有关G4介导的lncRNA-蛋白质相互作用的独特线索。
