Heidelberg Institute of Global Health (HIGH), Medical Faculty and University Hospital, Heidelberg University, Heidelberg.
Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
AIDS. 2024 Apr 1;38(5):723-730. doi: 10.1097/QAD.0000000000003815. Epub 2023 Dec 12.
A key factor for incidence of HIV is alcohol consumption. It impacts judgment and the probability to overlook risk-relevant information, which creates a pathway to reduced adherence to biomedical prevention and engagement in condomless sex. We strengthen the understanding of the link between alcohol consumption and risk of HIV among married men in sub-Saharan Africa (SSA), as we use comprehensive population-level data to provide robust evidence with high external validity.
Cross-sectional data analysis.
Based on data from Demographic and Health Surveys (DHS) from 20 countries and over 30 000 observations, a minimally and a fully adjusted model with country fixed effects examined the relationship between the men's alcohol consumption (observed by wife) and HIV status (blood test) while accounting for survey weights and controlling for potential confounders.
The data comprised a total of 35 108 men. Minimally adjusted [risk ratio (RR) 1.25; 95% confidence interval (CI) 1.14-1.37; P < 0.001] and fully adjusted (RR 1.26; 95% CI 1.15-1.38; P < 0.001) models showed a positive association between the men's alcohol consumption and HIV status. Two sensitivity analyses confirmed the association.
In line with previous experimental studies and theoretical framework, this study confirms a risk relationship between alcohol consumption and HIV. Thus, modern HIV/AIDS programs must continue to address the relationship in implementation of prevention and treatment programs.
艾滋病病毒感染的一个关键因素是饮酒。它会影响判断力和忽略与风险相关信息的可能性，从而导致对生物医学预防措施的遵从性降低，并增加无保护性行为的发生。我们利用综合的人口水平数据，为撒哈拉以南非洲（SSA）已婚男性中饮酒与艾滋病风险之间的联系提供了强有力的证据，以增强对这一联系的理解，这些证据具有高度的外部有效性。
横断面数据分析。
基于来自 20 个国家的人口动态调查（DHS）数据和超过 30000 个观察结果，使用最小和完全调整的模型以及国家固定效应，在考虑调查权重和控制潜在混杂因素的情况下，检验了男性饮酒（由妻子观察）与艾滋病毒状况（血液检测）之间的关系。
数据共包括 35108 名男性。最小调整模型[风险比（RR）1.25；95%置信区间（CI）1.14-1.37；P ＜ 0.001]和完全调整模型（RR 1.26；95% CI 1.15-1.38；P ＜ 0.001）均显示男性饮酒与艾滋病毒状况之间存在正相关关系。两项敏感性分析证实了这种关联。
与先前的实验研究和理论框架一致，本研究证实了饮酒与艾滋病病毒之间存在风险关系。因此，现代艾滋病病毒/艾滋病规划必须继续在预防和治疗方案的实施中解决这一关系。
