Sorbonne Université, Department of Maxillofacial Surgery and Stomatology, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Sorbonne Université, Department of Maxillofacial Surgery and Stomatology, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
J Stomatol Oral Maxillofac Surg. 2024 Sep;125(4):101737. doi: 10.1016/j.jormas.2023.101737. Epub 2023 Dec 12.
The prevalence of extensive skin cancers increases with the aging of the population. Surgical management is the gold standard of curative treatment while morbidity is not negligible. There are few data in the literature concerning extensive head and neck cutaneous cancers. The aim of this article is to report our experience of curative management of head and neck extensive skin cancers.
In this single-center retrospective observational study, we report a series of 17 patients with extensive skin facial cancers treated by surgery between 2013 and 2022 in the maxillofacial surgery department of the Pitié-Salpêtrière Hospital. We collected clinical, therapeutic, histological, and carcinologic data.
The median age of the patients was 66 years [35-94]. There were 9 male and 8 women. Scalp (39 %) and cheek (22 %) locations were the most frequent ones. The most frequent histological types were squamous cell carcinoma (61 %) and basal cell carcinoma (17 %). Three patients received neoadjuvant treatment. The surgical treatment consisted mainly of carcinological resection followed by one-stage reconstruction by free flap for 5 (30 %) patients and without reconstruction for primary for 12 (70 %) patients, of whom 8 benefited from secondary reconstruction. Five patients received adjuvant radiotherapy or radio-chemotherapy. With a median follow-up of 40 months (2-72), the median overall survival was 40 months (12-72).
We know that extensive skin cancers of the face have a good prognosis on condition that the carcinological and reconstructive requirements are respected. Surgery remains the cornerstone of treatment while the improvement of adjuvant therapies, in particular the rise of immunotherapies or other targeted therapies, may allow to limit recurrences.
随着人口老龄化，广泛皮肤癌的患病率增加。手术治疗是根治性治疗的金标准，但发病率也不容忽视。关于广泛头颈部皮肤癌的文献数据较少。本文旨在报告我们对头颈部广泛皮肤癌的根治性治疗经验。
在这项单中心回顾性观察研究中，我们报告了 2013 年至 2022 年间，我们在皮提-萨尔佩特里埃医院颌面外科部门对 17 例广泛皮肤面部癌症患者进行手术治疗的一系列病例。我们收集了临床、治疗、组织学和肿瘤学数据。
患者的中位年龄为 66 岁[35-94]。9 例为男性，8 例为女性。头皮（39%）和脸颊（22%）是最常见的部位。最常见的组织学类型是鳞状细胞癌（61%）和基底细胞癌（17%）。3 例患者接受了新辅助治疗。手术治疗主要包括癌性切除术，随后对 5 例患者进行了一期游离皮瓣重建，12 例患者未行原发性重建，其中 8 例患者进行了继发性重建。5 例患者接受了辅助放疗或放化疗。中位随访时间为 40 个月[2-72]，总生存中位数为 40 个月[12-72]。
我们知道，只要满足肿瘤学和重建要求，面部广泛皮肤癌的预后良好。手术仍然是治疗的基石，而辅助治疗的改善，特别是免疫治疗或其他靶向治疗的兴起，可能有助于限制复发。
