Stundys Domantas, Kučinskaitė Alvija, Gervickaitė Simona, Tarutytė Gabrielė, Grigaitienė Jūratė, Tutkuviene Janina, Jančorienė Ligita
Vilnius University, Faculty of Medicine, Institute of Clinical Medicine, Vilnius, 03101, Lithuania.
Vilnius University, Faculty of Medicine, Vilnius, 03101, Lithuania.
Pragmat Obs Res. 2024 Aug 5;15:103-119. doi: 10.2147/POR.S471307. eCollection 2024.
Facial basal cell carcinoma (BCC) poses significant challenges due to its potential for local destruction and impact on quality of life (QoL). Continuous research is necessary to identify novel factors influencing the quality of life within this demographic across diverse cultural settings. The aims of this study were to translate, culturally adapt, and validate the Lithuanian version of Skin Cancer Index, subsequently utilizing this questionnaire in the pilot phase of the study to achieve the following: (1) identify the differences in short- and long-term QoL, (2) establish empirical correlations between SCI scores and aesthetic facial regions, evaluate the potential differences between age, gender, and tumor size groups.
A prospective longitudinal study was conducted with 100 consecutive patients. The SCI was translated into Lithuanian language, with a rigorous assessment of its psychometric properties to confirm validity. Alongside hypothesis testing, a detailed analysis of variables was conducted. Statistical techniques, including t-tests and ANOVA, were employed to compare scores across demographic and clinical groups, with effect size calculations for further interpretation.
Our findings demonstrate that the Lithuanian SCI successfully fulfills the criteria established by the COSMIN checklist. Surgical treatment for facial BCC notably enhances QoL, particularly evident six months post-surgery. Analysis of SCI scores identified demographic and clinical factors associated with lower QoL, including female gender, treatment with skin plasty, and tumor sites in aesthetically sensitive areas like the cheek, nose, and eyelid.
The Lithuanian version of the SCI is a reliable and valid tool for assessing QoL in facial BCC patients. Our findings underscore the global relevance of understanding the multifactorial influences on QoL in BCC patients. Early diagnosis, less invasive treatment approaches, and tailored post-operative care are crucial in minimizing the psychological, social, and appearance-related burdens of facial BCC.
面部基底细胞癌（BCC）因其具有局部破坏的可能性以及对生活质量（QoL）的影响而带来重大挑战。有必要持续开展研究，以确定在不同文化背景下影响这一人群生活质量的新因素。本研究的目的是翻译、进行文化调适并验证立陶宛语版的皮肤癌指数，随后在研究的试点阶段使用该问卷以实现以下目标：（1）确定短期和长期生活质量的差异；（2）建立皮肤癌指数评分与面部美学区域之间的实证相关性，评估年龄、性别和肿瘤大小组之间的潜在差异。
对100例连续患者进行了一项前瞻性纵向研究。将皮肤癌指数翻译成立陶宛语，并对其心理测量特性进行严格评估以确认其有效性。除了假设检验外，还对变量进行了详细分析。采用包括t检验和方差分析在内的统计技术，比较不同人口统计学和临床组的评分，并计算效应量以进行进一步解释。
我们的研究结果表明，立陶宛语版的皮肤癌指数成功满足了COSMIN检查表所确立的标准。面部基底细胞癌的手术治疗显著提高了生活质量，术后六个月尤为明显。对皮肤癌指数评分的分析确定了与较低生活质量相关的人口统计学和临床因素，包括女性、皮肤整形治疗以及脸颊、鼻子和眼睑等美学敏感区域的肿瘤部位。
立陶宛语版的皮肤癌指数是评估面部基底细胞癌患者生活质量的可靠且有效的工具。我们的研究结果强调了理解基底细胞癌患者生活质量的多因素影响的全球相关性。早期诊断、侵入性较小的治疗方法以及量身定制的术后护理对于将面部基底细胞癌的心理、社会和外观相关负担降至最低至关重要。
