State Key Laboratory of Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Departments of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong; Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China; Departments of Nephrology and Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Mol Ther. 2024 Feb 7;32(2):313-324. doi: 10.1016/j.ymthe.2023.12.009. Epub 2023 Dec 12.
Renal fibrosis is a characteristic hallmark of chronic kidney disease (CKD) that ultimately results in renal failure, leaving patients with few therapeutic options. TGF-β is a master regulator of renal fibrosis and mediates progressive renal fibrosis via both canonical and noncanonical signaling pathways. In the canonical Smad signaling, Smad3 is a key mediator in tissue fibrosis and mediates renal fibrosis via a number of noncoding RNAs (ncRNAs). In this regard, targeting Smad3-dependent ncRNAs may offer a specific therapy for renal fibrosis. This review highlights the significance and innovation of TGF-β/Smad3-associated ncRNAs as biomarkers and therapeutic targets in renal fibrogenesis. In addition, the underlying mechanisms of these ncRNAs and their future perspectives in the treatment of renal fibrosis are discussed.
肾纤维化是慢性肾脏病（CKD）的一个特征性标志，最终导致肾衰竭，使患者治疗选择有限。TGF-β 是肾纤维化的主要调节因子，通过经典和非经典信号通路介导进行性肾纤维化。在经典的 Smad 信号转导中，Smad3 是组织纤维化的关键介质，并通过多种非编码 RNA（ncRNA）介导肾纤维化。在这方面，靶向 Smad3 依赖性 ncRNA 可能为肾纤维化提供一种特异性治疗方法。本综述强调了 TGF-β/Smad3 相关 ncRNA 作为肾纤维化发生的生物标志物和治疗靶点的重要性和创新性。此外，还讨论了这些 ncRNA 的潜在机制及其在治疗肾纤维化方面的未来前景。
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