西咪替丁对人体胃黏膜细胞增殖的影响。

Effect of cimetidine on gastric mucosal cell proliferation in man.

作者信息

Svendsen L B, Hansen O H, Larsen J K, Pedersen T, Johansen A

出版信息

Scand J Gastroenterol. 1986 Dec;21(10):1271-4. doi: 10.3109/00365528608996454.

Abstract

Seven duodenal ulcer patients were treated for 3 months with cimetidine. Before and after treatment endoscopic biopsy specimens were taken for autoradiographic estimation of cell proliferation in the gastric mucosa in the antral and fundic part of the stomach and from the duodenum. In all three areas the estimated labeling index was increased during medication with cimetidine. The increase in epithelial cell renewal may participate in the ulcer healing effect of cimetidine.

摘要

七名十二指肠溃疡患者接受了3个月的西咪替丁治疗。治疗前后，采集内镜活检标本，通过放射自显影法评估胃窦、胃底和十二指肠胃黏膜中的细胞增殖情况。在所有这三个区域，使用西咪替丁治疗期间，估计的标记指数均有所增加。上皮细胞更新的增加可能参与了西咪替丁的溃疡愈合作用。