Passeri M
Eur Neurol. 1978;17 Suppl 1:150-8. doi: 10.1159/000115019.
With the purpose to define the specific activity of substances acting on the cerebral circulation and metabolism, (-)eburnamonine and cinnarizine were compared in a double-blind study carried out in a group of 106 elderly patients suffering from established chronic brain ischemia. The photoscintigraphic and rheoencephalographic studies carried out on some of the patients showed that only (-)eburnamonine had a clear-cut activity on brain circulation. (-)Eburnamonine also showed an activity on kidney circulation. With regard to the clinical picture, a statistical evaluation of the results obtained showed that both drugs improve psychic disturbances and the overall clinical picture. Cinnarizine appears to influence, to a slightly greater extent, some neurological symptoms, while (-)eburnamonine exerts a significantly better action on daily living activities and general psychic efficiency.
为了确定作用于脑循环和代谢的物质的特定活性，在一组106例患有已确诊慢性脑缺血的老年患者中进行了一项双盲研究，对（-）埃布纳明和桂利嗪进行了比较。对部分患者进行的光闪烁造影和脑血流图研究表明，只有（-）埃布纳明对脑循环有明确的活性。（-）埃布纳明对肾循环也有活性。关于临床症状，对所得结果的统计学评估表明，两种药物均可改善精神障碍和整体临床症状。桂利嗪似乎在稍大程度上影响某些神经症状，而（-）埃布纳明对日常生活活动和一般精神效率的作用明显更好。
