Faculty of Medicine and University Hospital Cologne, Center of Anatomy, University of Cologne, Cologne, Germany.
J Morphol. 2024 Jan;285(1):e21665. doi: 10.1002/jmor.21665.
In embryonic development, the vertebral column arises from the sclerotomal compartment of the somites. The sclerotome is a mesenchymal cell mass which can be subdivided into several subpopulations specified by different regulatory mechanisms and giving rise to different parts of the vertebrae like vertebral body, vertebral arch, ribs, and vertebral joints. This review gives a short overview on the molecular and cellular basis of the formation of sclerotomal subdomains and the morphogenesis of their vertebral derivatives.
在胚胎发育过程中，脊柱来源于体节的软骨细胞区。软骨细胞区是一种间质细胞团，可通过不同的调节机制进一步细分为几个亚群，并分化为椎体、椎弓、肋骨和椎间关节等不同的椎体部分。本文简要概述了软骨细胞区形成的分子和细胞基础，以及其椎体衍生物的形态发生过程。
