University of Washington, Seattle, WA.
University of Alabama at Birmingham, Birmingham, AL.
J Acquir Immune Defic Syndr. 2024 Apr 1;95(4):377-382. doi: 10.1097/QAI.0000000000003362.
This study examined the relationships among adiposity, handgrip, physical function, inflammation (ie, senescence-associated secretory phenotype chemokines as biomarkers of aging and frailty), and sex hormones in aging people with HIV.
This cross-sectional exploratory study included 150 people with HIV aged ≥40 years (67.3% of participants were male). Our measures included (1) body mass index and waist circumference as measures of adiposity; (2) handgrip as a measure of muscle strength; (3) short physical performance battery as a measure of physical function; (4) interleukin-6, tumor necrosis factor alpha receptor II, high sensitivity C-reactive protein, C-X-C motif chemokine 10, and C-X3-C motif chemokine ligand 1 also known as fractalkine as senescence-associated secretory phenotype chemokines; and (5) free testosterone, estradiol, sex hormone-binding globulin, and dehydroepiandrosterone as sex hormones. Quantile regression analyses were used to identify relationships among inflammatory markers and hormones with age, adiposity, handgrip, and physical function.
Overall, 74% (n = 111) of participants were classified as overweight or obese and 53.3% (n = 80) presented with abdominal obesity. After controlling for age and sex, body mass index was positively associated with estradiol (β = 0.043, P < 0.01), and waist circumference was positively associated with high sensitivity C-reactive protein (β = 2.151, P < 0.01). After controlling for sex, age was positively associated with C-X-C motif chemokine 10 (β = 0.024, P = 0.03) and tumor necrosis factor alpha receptor II (β = 2.205, P = 0.01). After controlling for age and sex, short physical performance battery was negatively associated with dehydroepiandrosterone (β = -0.004, P = 0.01); no statistically significant associations were observed for handgrip.
Adiposity levels and aging were associated with inflammation (ie, C-X-C motif chemokine 10, tumor necrosis factor alpha receptor II, and high sensitivity C-reactive protein) among people with HIV aged 40 years and older.
本研究旨在探讨肥胖、握力、身体机能、炎症（即衰老相关分泌表型趋化因子作为衰老和虚弱的生物标志物）和性激素与感染 HIV 的老年人之间的关系。
本横断面探索性研究纳入了 150 名年龄≥40 岁的 HIV 感染者（67.3%的参与者为男性）。我们的测量指标包括：（1）体重指数和腰围作为肥胖的衡量指标；（2）握力作为肌肉力量的衡量指标；（3）简短体能测试作为身体机能的衡量指标；（4）白细胞介素-6、肿瘤坏死因子受体 II、高敏 C 反应蛋白、C-X-C 基序趋化因子 10 和 C-X3-C 基序趋化因子配体 1（也称为 fractalkine）作为衰老相关分泌表型趋化因子；（5）游离睾酮、雌二醇、性激素结合球蛋白和脱氢表雄酮作为性激素。使用分位数回归分析确定炎症标志物和激素与年龄、肥胖、握力和身体机能之间的关系。
总体而言，74%（n=111）的参与者超重或肥胖，53.3%（n=80）存在腹部肥胖。在校正年龄和性别后，体重指数与雌二醇呈正相关（β=0.043，P<0.01），腰围与高敏 C 反应蛋白呈正相关（β=2.151，P<0.01）。在校正性别后，年龄与 C-X-C 基序趋化因子 10 呈正相关（β=0.024，P=0.03）和肿瘤坏死因子受体 II 呈正相关（β=2.205，P=0.01）。在校正年龄和性别后，简短体能测试与脱氢表雄酮呈负相关（β=-0.004，P=0.01）；握力与炎症标志物无统计学显著相关性。
肥胖水平和衰老与感染 HIV 的 40 岁及以上人群的炎症（即 C-X-C 基序趋化因子 10、肿瘤坏死因子受体 II 和高敏 C 反应蛋白）相关。
