Chakraborty Nilanjan, Mitra Rusha, Dasgupta Disha, Ganguly Retwika, Acharya Krishnendu, Minkina Tatiana, Popova Victoria, Churyukina Ella, Keswani Chetan
Department of Botany, Scottish Church College (affiliated to University of Calcutta), Kolkata, 700006, India.
Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, 700019, India.
Plant Physiol Biochem. 2024 Jan;206:108272. doi: 10.1016/j.plaphy.2023.108272. Epub 2023 Dec 12.
Lipid peroxidation (LPO) is a complex process that, depending on the context, can either result in oxidative injury or promote redox homeostasis. LPO is a series of reactions in which polyunsaturated fatty acids are attacked by free radicals that result in the synthesis of lipid peroxides. LPO can alter membrane fluidity and operation and produce secondary products that amplify oxidative stress. LPO can activate cellular signaling pathways that promote antioxidant defense mechanisms that provide oxidative stress protection by elevating antioxidant enzyme action potentials. Enzymatic and nonenzymatic mechanisms tightly regulate LPO to prevent excessive LPO and its adverse consequences. This article emphasizes the dual nature of LPO as a mechanism that can both damage cells and regulate redox homeostasis. In addition, it also highlights the major enzymatic and nonenzymatic mechanisms that tightly regulate LPO to prevent excessive oxidative damage. More importantly, it emphasizes the importance of understanding the cellular and biochemical complexity of LPO for developing strategies targeting this process for efficient management of plant stress.
脂质过氧化（LPO）是一个复杂的过程，根据具体情况，它既可能导致氧化损伤，也可能促进氧化还原稳态。LPO是一系列反应，其中多不饱和脂肪酸受到自由基攻击，导致脂质过氧化物的合成。LPO可改变膜的流动性和功能，并产生放大氧化应激的次级产物。LPO可激活细胞信号通路，促进抗氧化防御机制，通过提高抗氧化酶的动作电位来提供氧化应激保护。酶促和非酶促机制严格调节LPO，以防止LPO过度及其产生的不良后果。本文强调了LPO作为一种既能损伤细胞又能调节氧化还原稳态的机制的双重性质。此外，它还突出了严格调节LPO以防止过度氧化损伤的主要酶促和非酶促机制。更重要的是，它强调了理解LPO的细胞和生化复杂性对于制定针对该过程的策略以有效管理植物胁迫的重要性。
