Cheng Ning, Dong Qiqi, Zhang Zhen, Wang Li, Chen Xiaojing, Wang Cheng
Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Neuron. 2024 Feb 21;112(4):646-660.e8. doi: 10.1016/j.neuron.2023.11.018. Epub 2023 Dec 14.
Egocentric representations of external items are essential for spatial navigation and memory. Here, we explored the neural mechanisms underlying egocentric processing in the retrosplenial cortex (RSC), a pivotal area for memory and navigation. Using one-photon and two-photon calcium imaging, we identified egocentric tuning for environment boundaries in dendrites, spines, and somas of RSC neurons (egocentric boundary cells) in the open-field task. Dendrites with egocentric tuning tended to have similarly tuned spines. We further identified egocentric neurons representing landmarks in a virtual navigation task or remembered cue location in a goal-oriented task, respectively. These neurons formed an independent population with egocentric boundary cells, suggesting that dedicated neurons with microscopic clustering of functional inputs shaped egocentric boundary processing in RSC and that RSC adopted a labeled line code with distinct classes of egocentric neurons responsible for representing different items in specific behavioral contexts, which could lead to efficient and flexible computation.
对外部物体的自我中心表征对于空间导航和记忆至关重要。在此，我们探究了后扣带回皮层（RSC）中自我中心处理的神经机制，RSC是记忆和导航的关键区域。使用单光子和双光子钙成像技术，我们在旷场任务中确定了RSC神经元（自我中心边界细胞）的树突、棘突和胞体对环境边界的自我中心调谐。具有自我中心调谐的树突往往具有类似调谐的棘突。我们还分别在虚拟导航任务中确定了代表地标或在目标导向任务中记住线索位置的自我中心神经元。这些神经元与自我中心边界细胞形成了一个独立的群体，这表明具有功能输入微观聚类的专用神经元塑造了RSC中的自我中心边界处理，并且RSC采用了标记线编码，其中不同类别的自我中心神经元负责在特定行为背景下表征不同的物体，这可能导致高效且灵活的计算。
