Department of Psychology, Cornell University, Ithaca, NY 14853, USA.
Cereb Cortex. 2021 Mar 31;31(5):2720-2728. doi: 10.1093/cercor/bhaa386.
The retrosplenial cortex (RSC) is thought to be involved in a variety of spatial and contextual memory processes. However, we do not know how contextual information might be encoded in the RSC or whether the RSC representations may be distinct from context representations seen in other brain regions such as the hippocampus. We recorded RSC neuronal responses while rats explored different environments and discovered 2 kinds of context representations: one involving a novel rate code in which neurons reliably fire at a higher rate in the preferred context regardless of spatial location, and a second involving context-dependent spatial firing patterns similar to those seen in the hippocampus. This suggests that the RSC employs a unique dual-factor representational mechanism to support contextual memory.
后隔核（RSC）被认为参与了多种空间和情境记忆过程。然而，我们不知道情境信息如何在 RSC 中进行编码，或者 RSC 的表示是否与海马等其他脑区中看到的情境表示不同。当大鼠探索不同环境时，我们记录了 RSC 神经元的反应，发现了 2 种情境表示：一种涉及新颖的速率编码，其中神经元在偏好的情境中可靠地以更高的速率发射，而与空间位置无关；另一种涉及与海马中所见类似的情境依赖的空间发射模式。这表明 RSC 采用了独特的双重因素表示机制来支持情境记忆。
